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Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer

Background and Objectives: Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is well known, yet only a few studies have been c...

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Autores principales: Allegra, Eugenia, Bianco, Maria Rita, Ralli, Massimo, Greco, Antonio, Angeletti, Diletta, de Vincentiis, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001944/
https://www.ncbi.nlm.nih.gov/pubmed/33804150
http://dx.doi.org/10.3390/medicina57030267
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author Allegra, Eugenia
Bianco, Maria Rita
Ralli, Massimo
Greco, Antonio
Angeletti, Diletta
de Vincentiis, Marco
author_facet Allegra, Eugenia
Bianco, Maria Rita
Ralli, Massimo
Greco, Antonio
Angeletti, Diletta
de Vincentiis, Marco
author_sort Allegra, Eugenia
collection PubMed
description Background and Objectives: Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is well known, yet only a few studies have been conducted on their role as risk factors of prognosis. The aim of the study was to assess the impact of clinical–demographic data on overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) in patients with advanced-stage laryngeal cancer (Stage III–IV) who underwent total laryngectomy. Materials and Methods: This retrospective study was carried out on patients with Stage III–IV laryngeal squamous cell carcinoma treated with total laryngectomy between 2004 and 2014. For each patient, clinical and anamnestic data were collected and collated in a database, including alcohol and smoking habits. Results: Considering the variable age, family history, alcohol, grading, subsite, stage, pT stage, pN stage, and adjuvant therapy, no statistical significance was found for five-year OS. Smoking was the only variable that was statistically significant (p = 0.0043). A relevant difference was noted in the five-year DFS between pN-negative and pN-positive tumors (74.3% vs. 55.26%, respectively; p = 0.056), and a statistically significant difference was found between non- and ≤20 cigarettes/day smokers and heavy smokers (77.78% vs. 53.66%, respectively; p = 0.021). The five-year disease-specific survival rate was 68.83%, and a significant difference was detected for the smoking and pN stage variables. Heavy smokers (43.90% died vs. 16.67% of the non- and ≤20 cigarettes/day smokers; p = 0.0057) and pN-positive (42.1% died vs. 20.51% of the pN-negative patients; p = 0.042) patients had a worse prognosis. Conclusion: Smoking in our study was found to be an important independent risk factor for worse OS and DSS in patients with advanced laryngeal cancer.
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spelling pubmed-80019442021-03-28 Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer Allegra, Eugenia Bianco, Maria Rita Ralli, Massimo Greco, Antonio Angeletti, Diletta de Vincentiis, Marco Medicina (Kaunas) Article Background and Objectives: Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is well known, yet only a few studies have been conducted on their role as risk factors of prognosis. The aim of the study was to assess the impact of clinical–demographic data on overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) in patients with advanced-stage laryngeal cancer (Stage III–IV) who underwent total laryngectomy. Materials and Methods: This retrospective study was carried out on patients with Stage III–IV laryngeal squamous cell carcinoma treated with total laryngectomy between 2004 and 2014. For each patient, clinical and anamnestic data were collected and collated in a database, including alcohol and smoking habits. Results: Considering the variable age, family history, alcohol, grading, subsite, stage, pT stage, pN stage, and adjuvant therapy, no statistical significance was found for five-year OS. Smoking was the only variable that was statistically significant (p = 0.0043). A relevant difference was noted in the five-year DFS between pN-negative and pN-positive tumors (74.3% vs. 55.26%, respectively; p = 0.056), and a statistically significant difference was found between non- and ≤20 cigarettes/day smokers and heavy smokers (77.78% vs. 53.66%, respectively; p = 0.021). The five-year disease-specific survival rate was 68.83%, and a significant difference was detected for the smoking and pN stage variables. Heavy smokers (43.90% died vs. 16.67% of the non- and ≤20 cigarettes/day smokers; p = 0.0057) and pN-positive (42.1% died vs. 20.51% of the pN-negative patients; p = 0.042) patients had a worse prognosis. Conclusion: Smoking in our study was found to be an important independent risk factor for worse OS and DSS in patients with advanced laryngeal cancer. MDPI 2021-03-15 /pmc/articles/PMC8001944/ /pubmed/33804150 http://dx.doi.org/10.3390/medicina57030267 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Allegra, Eugenia
Bianco, Maria Rita
Ralli, Massimo
Greco, Antonio
Angeletti, Diletta
de Vincentiis, Marco
Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title_full Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title_fullStr Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title_full_unstemmed Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title_short Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer
title_sort role of clinical-demographic data in survival rates of advanced laryngeal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001944/
https://www.ncbi.nlm.nih.gov/pubmed/33804150
http://dx.doi.org/10.3390/medicina57030267
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