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High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy

Over-immunosuppressed kidney transplant recipients are susceptible to malignancies and BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN). This study aimed to verify the association between BKPyV infection and urinary tract cancers (UTC). A total of 244 kidney transplant recipients were enroll...

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Autores principales: Li, Yi-Jung, Wu, Hsin-Hsu, Chen, Cheng-Hsu, Wang, Hsu-Han, Chiang, Yang-Jen, Hsu, Hsiang-Hao, Pang, See-Tong, Wang, Robert Y. L., Tian, Ya-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001968/
https://www.ncbi.nlm.nih.gov/pubmed/33799453
http://dx.doi.org/10.3390/v13030476
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author Li, Yi-Jung
Wu, Hsin-Hsu
Chen, Cheng-Hsu
Wang, Hsu-Han
Chiang, Yang-Jen
Hsu, Hsiang-Hao
Pang, See-Tong
Wang, Robert Y. L.
Tian, Ya-Chung
author_facet Li, Yi-Jung
Wu, Hsin-Hsu
Chen, Cheng-Hsu
Wang, Hsu-Han
Chiang, Yang-Jen
Hsu, Hsiang-Hao
Pang, See-Tong
Wang, Robert Y. L.
Tian, Ya-Chung
author_sort Li, Yi-Jung
collection PubMed
description Over-immunosuppressed kidney transplant recipients are susceptible to malignancies and BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN). This study aimed to verify the association between BKPyV infection and urinary tract cancers (UTC). A total of 244 kidney transplant recipients were enrolled at Chang Gung Memorial Hospital from June 2000 to February 2020. Biopsy-proven BKPyVAN patients (n = 17) had worse kidney function (eGFR: 26 ± 13.7 vs. 47.8 ± 31.0 mL/min/1.73 m(2)). The 5-year allograft survival rates for patients with and without BKPyVAN were 67% and 93%, respectively (p = 0.0002), while the 10-year patient survival was not different between the two groups. BKPyVAN patients had a significantly higher incidence of UTC compared to the non-BKPyVAN group (29.4% vs. 6.6%). Kaplan–Meier analysis showed that the UTC-free survival rate was significantly lower in BKPyVAN patients, and the onset of UTC was significantly shorter in BKPyVAN patients (53.4 vs. 108.9 months). The multivariate logistic regression analysis demonstrated that age (RR = 1.062) and BKVAN (RR = 6.459) were the most significant risk factors for the development of UTC. Our study demonstrates that BKPyVAN patients have greater allograft losses, higher incidence, a lower cancer-free survival rate, and an earlier onset with a higher relative risk of developing UTC compared to non-BKPyVAN patients.
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spelling pubmed-80019682021-03-28 High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy Li, Yi-Jung Wu, Hsin-Hsu Chen, Cheng-Hsu Wang, Hsu-Han Chiang, Yang-Jen Hsu, Hsiang-Hao Pang, See-Tong Wang, Robert Y. L. Tian, Ya-Chung Viruses Article Over-immunosuppressed kidney transplant recipients are susceptible to malignancies and BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN). This study aimed to verify the association between BKPyV infection and urinary tract cancers (UTC). A total of 244 kidney transplant recipients were enrolled at Chang Gung Memorial Hospital from June 2000 to February 2020. Biopsy-proven BKPyVAN patients (n = 17) had worse kidney function (eGFR: 26 ± 13.7 vs. 47.8 ± 31.0 mL/min/1.73 m(2)). The 5-year allograft survival rates for patients with and without BKPyVAN were 67% and 93%, respectively (p = 0.0002), while the 10-year patient survival was not different between the two groups. BKPyVAN patients had a significantly higher incidence of UTC compared to the non-BKPyVAN group (29.4% vs. 6.6%). Kaplan–Meier analysis showed that the UTC-free survival rate was significantly lower in BKPyVAN patients, and the onset of UTC was significantly shorter in BKPyVAN patients (53.4 vs. 108.9 months). The multivariate logistic regression analysis demonstrated that age (RR = 1.062) and BKVAN (RR = 6.459) were the most significant risk factors for the development of UTC. Our study demonstrates that BKPyVAN patients have greater allograft losses, higher incidence, a lower cancer-free survival rate, and an earlier onset with a higher relative risk of developing UTC compared to non-BKPyVAN patients. MDPI 2021-03-14 /pmc/articles/PMC8001968/ /pubmed/33799453 http://dx.doi.org/10.3390/v13030476 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Li, Yi-Jung
Wu, Hsin-Hsu
Chen, Cheng-Hsu
Wang, Hsu-Han
Chiang, Yang-Jen
Hsu, Hsiang-Hao
Pang, See-Tong
Wang, Robert Y. L.
Tian, Ya-Chung
High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title_full High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title_fullStr High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title_full_unstemmed High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title_short High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy
title_sort high incidence and early onset of urinary tract cancers in patients with bk polyomavirus associated nephropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001968/
https://www.ncbi.nlm.nih.gov/pubmed/33799453
http://dx.doi.org/10.3390/v13030476
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