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RNA Helicases as Shadow Modulators of Cell Cycle Progression

The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among th...

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Detalles Bibliográficos
Autores principales: Sergeeva, Olga, Zatsepin, Timofei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001981/
https://www.ncbi.nlm.nih.gov/pubmed/33804185
http://dx.doi.org/10.3390/ijms22062984
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author Sergeeva, Olga
Zatsepin, Timofei
author_facet Sergeeva, Olga
Zatsepin, Timofei
author_sort Sergeeva, Olga
collection PubMed
description The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases.
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spelling pubmed-80019812021-03-28 RNA Helicases as Shadow Modulators of Cell Cycle Progression Sergeeva, Olga Zatsepin, Timofei Int J Mol Sci Review The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases. MDPI 2021-03-15 /pmc/articles/PMC8001981/ /pubmed/33804185 http://dx.doi.org/10.3390/ijms22062984 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sergeeva, Olga
Zatsepin, Timofei
RNA Helicases as Shadow Modulators of Cell Cycle Progression
title RNA Helicases as Shadow Modulators of Cell Cycle Progression
title_full RNA Helicases as Shadow Modulators of Cell Cycle Progression
title_fullStr RNA Helicases as Shadow Modulators of Cell Cycle Progression
title_full_unstemmed RNA Helicases as Shadow Modulators of Cell Cycle Progression
title_short RNA Helicases as Shadow Modulators of Cell Cycle Progression
title_sort rna helicases as shadow modulators of cell cycle progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001981/
https://www.ncbi.nlm.nih.gov/pubmed/33804185
http://dx.doi.org/10.3390/ijms22062984
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