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RNA Helicases as Shadow Modulators of Cell Cycle Progression
The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001981/ https://www.ncbi.nlm.nih.gov/pubmed/33804185 http://dx.doi.org/10.3390/ijms22062984 |
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author | Sergeeva, Olga Zatsepin, Timofei |
author_facet | Sergeeva, Olga Zatsepin, Timofei |
author_sort | Sergeeva, Olga |
collection | PubMed |
description | The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases. |
format | Online Article Text |
id | pubmed-8001981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80019812021-03-28 RNA Helicases as Shadow Modulators of Cell Cycle Progression Sergeeva, Olga Zatsepin, Timofei Int J Mol Sci Review The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases. MDPI 2021-03-15 /pmc/articles/PMC8001981/ /pubmed/33804185 http://dx.doi.org/10.3390/ijms22062984 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sergeeva, Olga Zatsepin, Timofei RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title | RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title_full | RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title_fullStr | RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title_full_unstemmed | RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title_short | RNA Helicases as Shadow Modulators of Cell Cycle Progression |
title_sort | rna helicases as shadow modulators of cell cycle progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001981/ https://www.ncbi.nlm.nih.gov/pubmed/33804185 http://dx.doi.org/10.3390/ijms22062984 |
work_keys_str_mv | AT sergeevaolga rnahelicasesasshadowmodulatorsofcellcycleprogression AT zatsepintimofei rnahelicasesasshadowmodulatorsofcellcycleprogression |