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Exosomes as Pleiotropic Players in Pancreatic Cancer

Pancreatic cancer (PC) incidence is rising and due to late diagnosis, combined with unsatisfactory response to current therapeutic approaches, this tumor has an extremely high mortality rate. A better understanding of the mechanisms underlying pancreatic carcinogenesis is of paramount importance for...

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Autores principales: De Lellis, Laura, Florio, Rosalba, Di Bella, Maria Cristina, Brocco, Davide, Guidotti, Francesca, Tinari, Nicola, Grassadonia, Antonino, Lattanzio, Rossano, Cama, Alessandro, Veschi, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002012/
https://www.ncbi.nlm.nih.gov/pubmed/33803470
http://dx.doi.org/10.3390/biomedicines9030275
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author De Lellis, Laura
Florio, Rosalba
Di Bella, Maria Cristina
Brocco, Davide
Guidotti, Francesca
Tinari, Nicola
Grassadonia, Antonino
Lattanzio, Rossano
Cama, Alessandro
Veschi, Serena
author_facet De Lellis, Laura
Florio, Rosalba
Di Bella, Maria Cristina
Brocco, Davide
Guidotti, Francesca
Tinari, Nicola
Grassadonia, Antonino
Lattanzio, Rossano
Cama, Alessandro
Veschi, Serena
author_sort De Lellis, Laura
collection PubMed
description Pancreatic cancer (PC) incidence is rising and due to late diagnosis, combined with unsatisfactory response to current therapeutic approaches, this tumor has an extremely high mortality rate. A better understanding of the mechanisms underlying pancreatic carcinogenesis is of paramount importance for rational diagnostic and therapeutic approaches. Multiple lines of evidence have showed that exosomes are actively involved in intercellular communication by transferring their cargos of bioactive molecules to recipient cells within the tumor microenvironment and systemically. Intriguingly, exosomes may exert both protumor and antitumor effects, supporting or hampering processes that play a role in the pathogenesis and progression of PC, including shifts in tumor metabolism, proliferation, invasion, metastasis, and chemoresistance. They also have a dual role in PC immunomodulation, exerting immunosuppressive or immune enhancement effects through several mechanisms. PC-derived exosomes also induce systemic metabolic alterations, leading to the onset of diabetes and weight loss. Moreover, exosomes have been described as promising diagnostic and prognostic biomarkers for PC. Their potential application in PC therapy as drug carriers and therapeutic targets is under investigation. In this review, we provide an overview of the multiple roles played by exosomes in PC biology through their specific cargo biomolecules and of their potential exploitation in early diagnosis and treatment of PC.
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spelling pubmed-80020122021-03-28 Exosomes as Pleiotropic Players in Pancreatic Cancer De Lellis, Laura Florio, Rosalba Di Bella, Maria Cristina Brocco, Davide Guidotti, Francesca Tinari, Nicola Grassadonia, Antonino Lattanzio, Rossano Cama, Alessandro Veschi, Serena Biomedicines Review Pancreatic cancer (PC) incidence is rising and due to late diagnosis, combined with unsatisfactory response to current therapeutic approaches, this tumor has an extremely high mortality rate. A better understanding of the mechanisms underlying pancreatic carcinogenesis is of paramount importance for rational diagnostic and therapeutic approaches. Multiple lines of evidence have showed that exosomes are actively involved in intercellular communication by transferring their cargos of bioactive molecules to recipient cells within the tumor microenvironment and systemically. Intriguingly, exosomes may exert both protumor and antitumor effects, supporting or hampering processes that play a role in the pathogenesis and progression of PC, including shifts in tumor metabolism, proliferation, invasion, metastasis, and chemoresistance. They also have a dual role in PC immunomodulation, exerting immunosuppressive or immune enhancement effects through several mechanisms. PC-derived exosomes also induce systemic metabolic alterations, leading to the onset of diabetes and weight loss. Moreover, exosomes have been described as promising diagnostic and prognostic biomarkers for PC. Their potential application in PC therapy as drug carriers and therapeutic targets is under investigation. In this review, we provide an overview of the multiple roles played by exosomes in PC biology through their specific cargo biomolecules and of their potential exploitation in early diagnosis and treatment of PC. MDPI 2021-03-09 /pmc/articles/PMC8002012/ /pubmed/33803470 http://dx.doi.org/10.3390/biomedicines9030275 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
De Lellis, Laura
Florio, Rosalba
Di Bella, Maria Cristina
Brocco, Davide
Guidotti, Francesca
Tinari, Nicola
Grassadonia, Antonino
Lattanzio, Rossano
Cama, Alessandro
Veschi, Serena
Exosomes as Pleiotropic Players in Pancreatic Cancer
title Exosomes as Pleiotropic Players in Pancreatic Cancer
title_full Exosomes as Pleiotropic Players in Pancreatic Cancer
title_fullStr Exosomes as Pleiotropic Players in Pancreatic Cancer
title_full_unstemmed Exosomes as Pleiotropic Players in Pancreatic Cancer
title_short Exosomes as Pleiotropic Players in Pancreatic Cancer
title_sort exosomes as pleiotropic players in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002012/
https://www.ncbi.nlm.nih.gov/pubmed/33803470
http://dx.doi.org/10.3390/biomedicines9030275
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