COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab

Vaccines will play a key role in ending the COVID-19 pandemic. Vaccination against infections remains an important part of the management of patients with multiple sclerosis. However, there are limited data about the safety and efficacy of the currently available COVID-19 mRNA vaccines in patients w...

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Autores principales: Chilimuri, Sridhar, Mantri, Nikhitha, Gongati, Sudharsan, Zahid, Maleeha, Sun, Haozhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002140/
https://www.ncbi.nlm.nih.gov/pubmed/33806646
http://dx.doi.org/10.3390/vaccines9030219
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author Chilimuri, Sridhar
Mantri, Nikhitha
Gongati, Sudharsan
Zahid, Maleeha
Sun, Haozhe
author_facet Chilimuri, Sridhar
Mantri, Nikhitha
Gongati, Sudharsan
Zahid, Maleeha
Sun, Haozhe
author_sort Chilimuri, Sridhar
collection PubMed
description Vaccines will play a key role in ending the COVID-19 pandemic. Vaccination against infections remains an important part of the management of patients with multiple sclerosis. However, there are limited data about the safety and efficacy of the currently available COVID-19 mRNA vaccines in patients with multiple sclerosis receiving concurrent immunosuppressive therapies. Patients on B cell depleting therapy such as ocrelizumab have an attenuated vaccine response. We report the first case of COVID-19 vaccine failure in a patient with relapsing-remitting multiple sclerosis on B cell depleting therapy, ocrelizumab. We offer suggestions to improve vaccine efficacy in these patients.
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spelling pubmed-80021402021-03-28 COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab Chilimuri, Sridhar Mantri, Nikhitha Gongati, Sudharsan Zahid, Maleeha Sun, Haozhe Vaccines (Basel) Case Report Vaccines will play a key role in ending the COVID-19 pandemic. Vaccination against infections remains an important part of the management of patients with multiple sclerosis. However, there are limited data about the safety and efficacy of the currently available COVID-19 mRNA vaccines in patients with multiple sclerosis receiving concurrent immunosuppressive therapies. Patients on B cell depleting therapy such as ocrelizumab have an attenuated vaccine response. We report the first case of COVID-19 vaccine failure in a patient with relapsing-remitting multiple sclerosis on B cell depleting therapy, ocrelizumab. We offer suggestions to improve vaccine efficacy in these patients. MDPI 2021-03-04 /pmc/articles/PMC8002140/ /pubmed/33806646 http://dx.doi.org/10.3390/vaccines9030219 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Case Report
Chilimuri, Sridhar
Mantri, Nikhitha
Gongati, Sudharsan
Zahid, Maleeha
Sun, Haozhe
COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title_full COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title_fullStr COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title_full_unstemmed COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title_short COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab
title_sort covid-19 vaccine failure in a patient with multiple sclerosis on ocrelizumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002140/
https://www.ncbi.nlm.nih.gov/pubmed/33806646
http://dx.doi.org/10.3390/vaccines9030219
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