Cargando…
ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System
This article describes the design and the characterization of the ANTIGONE (ANalog To dIGital cONvErter) ASIC (Application Specific Integrated Circuit) built in AMS 0.35 m technology for low dc-current sensing. This energy-efficient ASIC was specifically designed to interface with multiple Ion-Sensi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002162/ https://www.ncbi.nlm.nih.gov/pubmed/33809491 http://dx.doi.org/10.3390/s21062074 |
_version_ | 1783671399126138880 |
---|---|
author | Voulgari, Evgenia Krummenacher, François Kayal, Maher |
author_facet | Voulgari, Evgenia Krummenacher, François Kayal, Maher |
author_sort | Voulgari, Evgenia |
collection | PubMed |
description | This article describes the design and the characterization of the ANTIGONE (ANalog To dIGital cONvErter) ASIC (Application Specific Integrated Circuit) built in AMS 0.35 m technology for low dc-current sensing. This energy-efficient ASIC was specifically designed to interface with multiple Ion-Sensitive Field-Effect Transistors (ISFETs) and detect biomarkers like pH, [Formula: see text] , [Formula: see text] and [Formula: see text] in human sweat. The ISFET-ASIC system can allow real-time noninvasive and continuous health monitoring. The ANTIGONE ASIC architecture is based on the current-to-frequency converter through the charge balancing principle. The same front-end can digitize multiple currents produced by four sweat ISFET sensors in time multiplexing. The front-end demonstrates good linearity over a dynamic range that spans from 1 pA up to 500 nA. The consumed energy per conversion is less than 1 J. The chip is programmable and works in eight different modes of operation. The system uses a standard Serial Peripheral Interface (SPI) to configure, control and read the digitally converted sensor data. The chip is controlled by a portable device over Bluetooth Low Energy (BLE) through a Microcontroller Unit (MCU). The sweat sensing system is part of a bigger wearable platform that exploits the convergence of multiparameter biosensors and environmental sensors for personalized and preventive healthcare. |
format | Online Article Text |
id | pubmed-8002162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80021622021-03-28 ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System Voulgari, Evgenia Krummenacher, François Kayal, Maher Sensors (Basel) Article This article describes the design and the characterization of the ANTIGONE (ANalog To dIGital cONvErter) ASIC (Application Specific Integrated Circuit) built in AMS 0.35 m technology for low dc-current sensing. This energy-efficient ASIC was specifically designed to interface with multiple Ion-Sensitive Field-Effect Transistors (ISFETs) and detect biomarkers like pH, [Formula: see text] , [Formula: see text] and [Formula: see text] in human sweat. The ISFET-ASIC system can allow real-time noninvasive and continuous health monitoring. The ANTIGONE ASIC architecture is based on the current-to-frequency converter through the charge balancing principle. The same front-end can digitize multiple currents produced by four sweat ISFET sensors in time multiplexing. The front-end demonstrates good linearity over a dynamic range that spans from 1 pA up to 500 nA. The consumed energy per conversion is less than 1 J. The chip is programmable and works in eight different modes of operation. The system uses a standard Serial Peripheral Interface (SPI) to configure, control and read the digitally converted sensor data. The chip is controlled by a portable device over Bluetooth Low Energy (BLE) through a Microcontroller Unit (MCU). The sweat sensing system is part of a bigger wearable platform that exploits the convergence of multiparameter biosensors and environmental sensors for personalized and preventive healthcare. MDPI 2021-03-16 /pmc/articles/PMC8002162/ /pubmed/33809491 http://dx.doi.org/10.3390/s21062074 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Voulgari, Evgenia Krummenacher, François Kayal, Maher ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title | ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title_full | ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title_fullStr | ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title_full_unstemmed | ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title_short | ANTIGONE: A Programmable Energy-Efficient Current Digitizer for an ISFET Wearable Sweat Sensing System |
title_sort | antigone: a programmable energy-efficient current digitizer for an isfet wearable sweat sensing system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002162/ https://www.ncbi.nlm.nih.gov/pubmed/33809491 http://dx.doi.org/10.3390/s21062074 |
work_keys_str_mv | AT voulgarievgenia antigoneaprogrammableenergyefficientcurrentdigitizerforanisfetwearablesweatsensingsystem AT krummenacherfrancois antigoneaprogrammableenergyefficientcurrentdigitizerforanisfetwearablesweatsensingsystem AT kayalmaher antigoneaprogrammableenergyefficientcurrentdigitizerforanisfetwearablesweatsensingsystem |