Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na(V)1.7 Can Be Predicted Using Accurate Free-Energy Calculations

Gating modifier toxins (GMTs) isolated from venomous organisms such as Protoxin-II (ProTx-II) and Huwentoxin-IV (HwTx-IV) that inhibit the voltage-gated sodium channel Na(V)1.7 by binding to its voltage-sensing domain II (VSDII) have been extensively investigated as non-opioid analgesics. However, r...

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Detalles Bibliográficos
Autores principales: Katz, Dana, Sindhikara, Dan, DiMattia, Michael, Leffler, Abba E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002187/
https://www.ncbi.nlm.nih.gov/pubmed/33800031
http://dx.doi.org/10.3390/toxins13030193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002187/
https://www.ncbi.nlm.nih.gov/pubmed/33800031
http://dx.doi.org/10.3390/toxins13030193

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