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Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl...

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Detalles Bibliográficos
Autores principales:	López-Francés, Adrián, del Corte, Xabier, Martínez de Marigorta, Edorta, Palacios, Francisco, Vicario, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002371/ https://www.ncbi.nlm.nih.gov/pubmed/33809715 http://dx.doi.org/10.3390/molecules26061654

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