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Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji

The introduction of the rotavirus vaccine, Rotarix, into the Fiji National Immunisation Program in 2012 has reduced the burden of rotavirus disease and hospitalisations in children less than 5 years of age. The aim of this study was to describe the pattern of rotavirus genotype diversity from 2005 t...

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Autores principales: Thomas, Sarah, Donato, Celeste M., Covea, Sokoveti, Ratu, Felisita T., Jenney, Adam W. J., Reyburn, Rita, Sahu Khan, Aalisha, Rafai, Eric, Grabovac, Varja, Serhan, Fatima, Bines, Julie E., Russell, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002601/
https://www.ncbi.nlm.nih.gov/pubmed/33802966
http://dx.doi.org/10.3390/pathogens10030358
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author Thomas, Sarah
Donato, Celeste M.
Covea, Sokoveti
Ratu, Felisita T.
Jenney, Adam W. J.
Reyburn, Rita
Sahu Khan, Aalisha
Rafai, Eric
Grabovac, Varja
Serhan, Fatima
Bines, Julie E.
Russell, Fiona M.
author_facet Thomas, Sarah
Donato, Celeste M.
Covea, Sokoveti
Ratu, Felisita T.
Jenney, Adam W. J.
Reyburn, Rita
Sahu Khan, Aalisha
Rafai, Eric
Grabovac, Varja
Serhan, Fatima
Bines, Julie E.
Russell, Fiona M.
author_sort Thomas, Sarah
collection PubMed
description The introduction of the rotavirus vaccine, Rotarix, into the Fiji National Immunisation Program in 2012 has reduced the burden of rotavirus disease and hospitalisations in children less than 5 years of age. The aim of this study was to describe the pattern of rotavirus genotype diversity from 2005 to 2018; to investigate changes following the introduction of the rotavirus vaccine in Fiji. Faecal samples from children less than 5 years with acute diarrhoea between 2005 to 2018 were analysed at the WHO Rotavirus Regional Reference Laboratory at the Murdoch Children’s Research Institute, Melbourne, Australia, and positive samples were serotyped by EIA (2005–2006) or genotyped by heminested RT-PCR (2007 onwards). We observed a transient increase in the zoonotic strain equine-like G3P[8] in the initial period following vaccine introduction. G1P[8] and G2P[4], dominant genotypes prior to vaccine introduction, have not been detected since 2015 and 2014, respectively. A decrease in rotavirus genotypes G2P[8], G3P[6], G8P[8] and G9P[8] was also observed following vaccine introduction. Monitoring the rotavirus genotypes that cause diarrhoeal disease in children in Fiji is important to ensure that the rotavirus vaccine will continue to be protective and to enable early detection of new vaccine escape strains if this occurs.
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spelling pubmed-80026012021-03-28 Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji Thomas, Sarah Donato, Celeste M. Covea, Sokoveti Ratu, Felisita T. Jenney, Adam W. J. Reyburn, Rita Sahu Khan, Aalisha Rafai, Eric Grabovac, Varja Serhan, Fatima Bines, Julie E. Russell, Fiona M. Pathogens Article The introduction of the rotavirus vaccine, Rotarix, into the Fiji National Immunisation Program in 2012 has reduced the burden of rotavirus disease and hospitalisations in children less than 5 years of age. The aim of this study was to describe the pattern of rotavirus genotype diversity from 2005 to 2018; to investigate changes following the introduction of the rotavirus vaccine in Fiji. Faecal samples from children less than 5 years with acute diarrhoea between 2005 to 2018 were analysed at the WHO Rotavirus Regional Reference Laboratory at the Murdoch Children’s Research Institute, Melbourne, Australia, and positive samples were serotyped by EIA (2005–2006) or genotyped by heminested RT-PCR (2007 onwards). We observed a transient increase in the zoonotic strain equine-like G3P[8] in the initial period following vaccine introduction. G1P[8] and G2P[4], dominant genotypes prior to vaccine introduction, have not been detected since 2015 and 2014, respectively. A decrease in rotavirus genotypes G2P[8], G3P[6], G8P[8] and G9P[8] was also observed following vaccine introduction. Monitoring the rotavirus genotypes that cause diarrhoeal disease in children in Fiji is important to ensure that the rotavirus vaccine will continue to be protective and to enable early detection of new vaccine escape strains if this occurs. MDPI 2021-03-17 /pmc/articles/PMC8002601/ /pubmed/33802966 http://dx.doi.org/10.3390/pathogens10030358 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Thomas, Sarah
Donato, Celeste M.
Covea, Sokoveti
Ratu, Felisita T.
Jenney, Adam W. J.
Reyburn, Rita
Sahu Khan, Aalisha
Rafai, Eric
Grabovac, Varja
Serhan, Fatima
Bines, Julie E.
Russell, Fiona M.
Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title_full Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title_fullStr Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title_full_unstemmed Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title_short Genotype Diversity before and after the Introduction of a Rotavirus Vaccine into the National Immunisation Program in Fiji
title_sort genotype diversity before and after the introduction of a rotavirus vaccine into the national immunisation program in fiji
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002601/
https://www.ncbi.nlm.nih.gov/pubmed/33802966
http://dx.doi.org/10.3390/pathogens10030358
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