Cargando…

Auraptene Enhances Junction Assembly in Cerebrovascular Endothelial Cells by Promoting Resilience to Mitochondrial Stress through Activation of Antioxidant Enzymes and mtUPR

Junctional proteins in cerebrovascular endothelial cells are essential for maintaining the barrier function of the blood-brain barrier (BBB), thus protecting the brain from the infiltration of pathogens. The present study showed that the potential therapeutic natural compound auraptene (AUR) enhance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Min Joung, Jang, Yunseon, Zhu, Jiebo, Namgung, Eunji, Go, Dahyun, Seo, Changjun, Ju, Xianshu, Cui, Jianchen, Lee, Yu Lim, Kang, Hyoeun, Kim, Hyeongseok, Chung, Woosuk, Heo, Jun Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002628/ https://www.ncbi.nlm.nih.gov/pubmed/33802930 http://dx.doi.org/10.3390/antiox10030475

Ejemplares similares

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR
por: Poveda-Huertes, Daniel, et al.
Publicado: (2021)

mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases
por: Cilleros-Holgado, Paula, et al.
Publicado: (2023)

Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
por: Aldridge, Jonathan E., et al.
Publicado: (2007)

Auraptene Mitigates Parkinson’s Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species
por: Jang, Yunseon, et al.
Publicado: (2019)

An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates
por: Poveda-Huertes, Daniel, et al.
Publicado: (2020)

Reactive microglia and mitochondrial unfolded protein response following ventriculomegaly and behavior defects in kaolin-induced hydrocephalus
por: Zhu, Jiebo, et al.
Publicado: (2022)

Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP(+) in human SH-SY5Y neuroblastoma cells
por: Cai, Yousheng, et al.
Publicado: (2020)

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
por: Jang, Yunseon, et al.
Publicado: (2020)

UPR(mt) and coordinated UPR(ER) in type 2 diabetes
por: Kang, Zhanfang, et al.
Publicado: (2022)

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation
por: Jang, Yunseon, et al.
Publicado: (2015)

Sensing the Stress: A Role for the UPR(mt) and UPR(am) in the Quality Control of Mitochondria
por: Callegari, Sylvie, et al.
Publicado: (2018)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

The UPR(mt) preserves mitochondrial import to extend lifespan
por: Xin, Nan, et al.
Publicado: (2022)

Temporal landscape of mitochondrial proteostasis governed by the UPR(mt)
por: Uoselis, Louise, et al.
Publicado: (2023)

Mitochondria Retrograde Signaling and the UPR(mt): Where Are We in Mammals?
por: Arnould, Thierry, et al.
Publicado: (2015)

Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson's Disease Model
por: Han, Jeongsu, et al.
Publicado: (2019)

A Review of Auraptene as an Anticancer Agent
por: Tayarani-Najaran, Zahra, et al.
Publicado: (2021)

Mitochondrial dysfunction, UPR(mt) signaling, and targeted therapy in metastasis tumor
por: Keerthiga, Rajendiran, et al.
Publicado: (2021)

The mitochondrial unfolded protein response (UPR(mt)) protects against osteoarthritis
por: Zhou, Zhibin, et al.
Publicado: (2022)

A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities
por: Jang, Yunseon, et al.
Publicado: (2017)

Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus
por: Jang, Yunseon, et al.
Publicado: (2021)

ATF5 Attenuates the Secretion of Pro-Inflammatory Cytokines in Activated Microglia
por: Zhu, Jiebo, et al.
Publicado: (2023)

UPR(mt) activation improves pathological alterations in cellular models of mitochondrial diseases
por: Suárez-Rivero, Juan M., et al.
Publicado: (2022)

Role of UPR(mt) and mitochondrial dynamics in host immunity: it takes two to tango
por: Kumar, Manmohan, et al.
Publicado: (2023)

Mitochondrial translational defect extends lifespan in C. elegans by activating UPR(mt)
por: Guo, Miaomiao, et al.
Publicado: (2023)

The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in Mice
por: Kim, Yun-Hee, et al.
Publicado: (2022)

Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice
por: Cui, Jianchen, et al.
Publicado: (2022)

UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication
por: Melber, Andrew, et al.
Publicado: (2018)

Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR(mt) in the hypothalamus of mice
por: Braga, Renata R., et al.
Publicado: (2021)

The mitochondrial unfolded protein response (UPR(mt)): shielding against toxicity to mitochondria in cancer
por: Inigo, Joseph R., et al.
Publicado: (2022)

Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain
por: Okuyama, Satoshi, et al.
Publicado: (2015)

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis
por: Kenny, T C, et al.
Publicado: (2017)

UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
por: Shpilka, Tomer, et al.
Publicado: (2021)

Genome-wide RNAi screen for regulators of UPR(mt) in Caenorhabditis elegans mutants with defects in mitochondrial fusion
por: Haeussler, Simon, et al.
Publicado: (2021)

Physical exercise elicits UPR(mt) in the skeletal muscle: The role of c-Jun N-terminal kinase
por: Gaspar, Rodrigo Stellzer, et al.
Publicado: (2023)

The UPR for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2007)

Neurotrophic Effect of Citrus Auraptene: Neuritogenic Activity in PC12 Cells
por: Furukawa, Yoshiko, et al.
Publicado: (2012)

Protective Effects of Auraptene against Free Radical-Induced Erythrocytes Damage
por: Jamialahmadi, Khadijeh, et al.
Publicado: (2022)

TLR22-Induced Pro-Apoptotic mtROS Abets UPR(mt)-Mediated Mitochondrial Fission in Aeromonas hydrophila-Infected Headkidney Macrophages of Clarias gariepinus
por: Kumar, Manmohan, et al.
Publicado: (2022)

A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption
por: Lee, Min Joung, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pihb1p6k660elibrlr79nghd7h