Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-rela...

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Autores principales: László, Loretta, Kurilla, Anita, Takács, Tamás, Kudlik, Gyöngyi, Koprivanacz, Kitti, Buday, László, Vas, Virag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002639/
https://www.ncbi.nlm.nih.gov/pubmed/33802849
http://dx.doi.org/10.3390/cells10030667
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author László, Loretta
Kurilla, Anita
Takács, Tamás
Kudlik, Gyöngyi
Koprivanacz, Kitti
Buday, László
Vas, Virag
author_facet László, Loretta
Kurilla, Anita
Takács, Tamás
Kudlik, Gyöngyi
Koprivanacz, Kitti
Buday, László
Vas, Virag
author_sort László, Loretta
collection PubMed
description The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC.
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spelling pubmed-80026392021-03-28 Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology László, Loretta Kurilla, Anita Takács, Tamás Kudlik, Gyöngyi Koprivanacz, Kitti Buday, László Vas, Virag Cells Review The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC. MDPI 2021-03-17 /pmc/articles/PMC8002639/ /pubmed/33802849 http://dx.doi.org/10.3390/cells10030667 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
László, Loretta
Kurilla, Anita
Takács, Tamás
Kudlik, Gyöngyi
Koprivanacz, Kitti
Buday, László
Vas, Virag
Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title_full Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title_fullStr Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title_full_unstemmed Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title_short Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
title_sort recent updates on the significance of kras mutations in colorectal cancer biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002639/
https://www.ncbi.nlm.nih.gov/pubmed/33802849
http://dx.doi.org/10.3390/cells10030667
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