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Genetic Markers of Genome Rearrangements in Helicobacter pylori
Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements. Identifying the association of these elements with rearrangements can pave the way to understan...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002640/ https://www.ncbi.nlm.nih.gov/pubmed/33802974 http://dx.doi.org/10.3390/microorganisms9030621 |
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author | Noureen, Mehwish Kawashima, Takeshi Arita, Masanori |
author_facet | Noureen, Mehwish Kawashima, Takeshi Arita, Masanori |
author_sort | Noureen, Mehwish |
collection | PubMed |
description | Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements. Identifying the association of these elements with rearrangements can pave the way to understand its genome evolution. We analyzed the order of orthologous genes among 72 publicly available complete genomes to identify large genome rearrangements, and rearrangement breakpoints were compared with the positions of insertion sequences, genomic islands, and restriction modification genes. Comparison of the shared inversions revealed the conserved genomic elements across strains from different geographical locations. Some were region-specific and others were global, indicating that highly shared rearrangements and their markers were more ancestral than strain—or region—specific ones. The locations of genomic islands were an important factor for the occurrence of the rearrangements. Comparative genomics helps to evaluate the conservation of various elements contributing to the diversity across genomes. |
format | Online Article Text |
id | pubmed-8002640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80026402021-03-28 Genetic Markers of Genome Rearrangements in Helicobacter pylori Noureen, Mehwish Kawashima, Takeshi Arita, Masanori Microorganisms Communication Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements. Identifying the association of these elements with rearrangements can pave the way to understand its genome evolution. We analyzed the order of orthologous genes among 72 publicly available complete genomes to identify large genome rearrangements, and rearrangement breakpoints were compared with the positions of insertion sequences, genomic islands, and restriction modification genes. Comparison of the shared inversions revealed the conserved genomic elements across strains from different geographical locations. Some were region-specific and others were global, indicating that highly shared rearrangements and their markers were more ancestral than strain—or region—specific ones. The locations of genomic islands were an important factor for the occurrence of the rearrangements. Comparative genomics helps to evaluate the conservation of various elements contributing to the diversity across genomes. MDPI 2021-03-17 /pmc/articles/PMC8002640/ /pubmed/33802974 http://dx.doi.org/10.3390/microorganisms9030621 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Communication Noureen, Mehwish Kawashima, Takeshi Arita, Masanori Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title | Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title_full | Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title_fullStr | Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title_full_unstemmed | Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title_short | Genetic Markers of Genome Rearrangements in Helicobacter pylori |
title_sort | genetic markers of genome rearrangements in helicobacter pylori |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002640/ https://www.ncbi.nlm.nih.gov/pubmed/33802974 http://dx.doi.org/10.3390/microorganisms9030621 |
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