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Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study

To evaluate the effect that an education-based Antimicrobial stewardship program (ASP) implemented in two hospitals in southern Italy had on the quality and appropriateness of antibiotic prescription. We conducted a multicenter observational study in two hospitals in the Campania region. Only some d...

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Autores principales: Calò, Federica, Onorato, Lorenzo, Macera, Margherita, Di Caprio, Giovanni, Monari, Caterina, Russo, Antonio, Galdieri, Anna, Giordano, Antonio, Cuccaro, Patrizia, Coppola, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002962/
https://www.ncbi.nlm.nih.gov/pubmed/33803069
http://dx.doi.org/10.3390/antibiotics10030314
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author Calò, Federica
Onorato, Lorenzo
Macera, Margherita
Di Caprio, Giovanni
Monari, Caterina
Russo, Antonio
Galdieri, Anna
Giordano, Antonio
Cuccaro, Patrizia
Coppola, Nicola
author_facet Calò, Federica
Onorato, Lorenzo
Macera, Margherita
Di Caprio, Giovanni
Monari, Caterina
Russo, Antonio
Galdieri, Anna
Giordano, Antonio
Cuccaro, Patrizia
Coppola, Nicola
author_sort Calò, Federica
collection PubMed
description To evaluate the effect that an education-based Antimicrobial stewardship program (ASP) implemented in two hospitals in southern Italy had on the quality and appropriateness of antibiotic prescription. We conducted a multicenter observational study in two hospitals in the Campania region. Only some departments of both hospitals were already participating in the ASP. We collected data on all patients admitted on the day of evaluation in antibiotic therapy or prophylaxis through a case report form. The primary outcome was to investigate the difference in the appropriateness of the antibiotic prescriptive practice in the departments that had joined the ASP and in those that had not participated in the project (non-ASP). The total number of patients assessed was 486. Of these, 78 (16.05%) were in antibiotic prophylaxis and 130 (26.7%) in antibiotic therapy. The prescriptive appropriateness was better in the units that had joined ASP than in those that had not, with respectively 65.8% versus 22.7% (p < 0.01). Patients in the non-ASP units more frequently received unnecessary antibiotics (44.9% versus 0%, p = 0.03) and, as surgical prophylaxis, the use of antibiotics not recommended by the guidelines (44.2% versus 0%, p = 0.036). Multivariable analysis of the factors associated with prescriptive appropriateness identified ASP units (p = 0.02) and bloodstream or cardiovascular infections (p = 0.03) as independent predictors of better prescriptive appropriateness. The findings of the present study reinforce the importance of adopting an educational ASP to improve the quality of antimicrobial prescription in clinical practice.
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spelling pubmed-80029622021-03-28 Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study Calò, Federica Onorato, Lorenzo Macera, Margherita Di Caprio, Giovanni Monari, Caterina Russo, Antonio Galdieri, Anna Giordano, Antonio Cuccaro, Patrizia Coppola, Nicola Antibiotics (Basel) Article To evaluate the effect that an education-based Antimicrobial stewardship program (ASP) implemented in two hospitals in southern Italy had on the quality and appropriateness of antibiotic prescription. We conducted a multicenter observational study in two hospitals in the Campania region. Only some departments of both hospitals were already participating in the ASP. We collected data on all patients admitted on the day of evaluation in antibiotic therapy or prophylaxis through a case report form. The primary outcome was to investigate the difference in the appropriateness of the antibiotic prescriptive practice in the departments that had joined the ASP and in those that had not participated in the project (non-ASP). The total number of patients assessed was 486. Of these, 78 (16.05%) were in antibiotic prophylaxis and 130 (26.7%) in antibiotic therapy. The prescriptive appropriateness was better in the units that had joined ASP than in those that had not, with respectively 65.8% versus 22.7% (p < 0.01). Patients in the non-ASP units more frequently received unnecessary antibiotics (44.9% versus 0%, p = 0.03) and, as surgical prophylaxis, the use of antibiotics not recommended by the guidelines (44.2% versus 0%, p = 0.036). Multivariable analysis of the factors associated with prescriptive appropriateness identified ASP units (p = 0.02) and bloodstream or cardiovascular infections (p = 0.03) as independent predictors of better prescriptive appropriateness. The findings of the present study reinforce the importance of adopting an educational ASP to improve the quality of antimicrobial prescription in clinical practice. MDPI 2021-03-17 /pmc/articles/PMC8002962/ /pubmed/33803069 http://dx.doi.org/10.3390/antibiotics10030314 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Calò, Federica
Onorato, Lorenzo
Macera, Margherita
Di Caprio, Giovanni
Monari, Caterina
Russo, Antonio
Galdieri, Anna
Giordano, Antonio
Cuccaro, Patrizia
Coppola, Nicola
Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title_full Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title_fullStr Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title_full_unstemmed Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title_short Impact of an Education-Based Antimicrobial Stewardship Program on the Appropriateness of Antibiotic Prescribing: Results of a Multicenter Observational Study
title_sort impact of an education-based antimicrobial stewardship program on the appropriateness of antibiotic prescribing: results of a multicenter observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002962/
https://www.ncbi.nlm.nih.gov/pubmed/33803069
http://dx.doi.org/10.3390/antibiotics10030314
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