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Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris

Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized...

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Autores principales: Billamboz, Muriel, Fatima, Zeeshan, Hameed, Saif, Jawhara, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003017/
https://www.ncbi.nlm.nih.gov/pubmed/33803604
http://dx.doi.org/10.3390/microorganisms9030634
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author Billamboz, Muriel
Fatima, Zeeshan
Hameed, Saif
Jawhara, Samir
author_facet Billamboz, Muriel
Fatima, Zeeshan
Hameed, Saif
Jawhara, Samir
author_sort Billamboz, Muriel
collection PubMed
description Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.
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spelling pubmed-80030172021-03-28 Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris Billamboz, Muriel Fatima, Zeeshan Hameed, Saif Jawhara, Samir Microorganisms Review Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies. MDPI 2021-03-18 /pmc/articles/PMC8003017/ /pubmed/33803604 http://dx.doi.org/10.3390/microorganisms9030634 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Billamboz, Muriel
Fatima, Zeeshan
Hameed, Saif
Jawhara, Samir
Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title_full Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title_fullStr Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title_full_unstemmed Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title_short Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
title_sort promising drug candidates and new strategies for fighting against the emerging superbug candida auris
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003017/
https://www.ncbi.nlm.nih.gov/pubmed/33803604
http://dx.doi.org/10.3390/microorganisms9030634
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