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Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor

Many studies concern the generation of lossy mode resonances (LMRs) using metallic oxide thin films that are deposited on optical fiber. However, the LMR-based optical fiber sensors are frangible, do not allow easy surface modification, and are not suited to mass production. This study proposes an e...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Cheng, Chen, Liang-Yü
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003139/
https://www.ncbi.nlm.nih.gov/pubmed/33803880
http://dx.doi.org/10.3390/bios11030086
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author Lin, Yu-Cheng
Chen, Liang-Yü
author_facet Lin, Yu-Cheng
Chen, Liang-Yü
author_sort Lin, Yu-Cheng
collection PubMed
description Many studies concern the generation of lossy mode resonances (LMRs) using metallic oxide thin films that are deposited on optical fiber. However, the LMR-based optical fiber sensors are frangible, do not allow easy surface modification, and are not suited to mass production. This study proposes an electrical field-induced LMR-based biosensor with an optical planar waveguide to replace surface modification and allow the mass production of protein biosensors and accelerate the speed of the analyte to decrease the detection time. Experimentally, the biosensor is evaluated using charged serum albumin molecules and characterized in terms of the LMR wavelength shift using an externally applied voltage for different durations. The externally applied voltage generates a significant electric field, which drives the non-neutralized biomolecules and increases the LMR wavelength shift. Our experimental results demonstrate that there are two different mechanisms of adsorption of serum albumin molecules for short-term and long-term observations. These are used to calculate the sensitivity of the biosensor. This electrical field-induced method is highly significant for the development and fabrication of LMR-based biosensors.
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spelling pubmed-80031392021-03-28 Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor Lin, Yu-Cheng Chen, Liang-Yü Biosensors (Basel) Article Many studies concern the generation of lossy mode resonances (LMRs) using metallic oxide thin films that are deposited on optical fiber. However, the LMR-based optical fiber sensors are frangible, do not allow easy surface modification, and are not suited to mass production. This study proposes an electrical field-induced LMR-based biosensor with an optical planar waveguide to replace surface modification and allow the mass production of protein biosensors and accelerate the speed of the analyte to decrease the detection time. Experimentally, the biosensor is evaluated using charged serum albumin molecules and characterized in terms of the LMR wavelength shift using an externally applied voltage for different durations. The externally applied voltage generates a significant electric field, which drives the non-neutralized biomolecules and increases the LMR wavelength shift. Our experimental results demonstrate that there are two different mechanisms of adsorption of serum albumin molecules for short-term and long-term observations. These are used to calculate the sensitivity of the biosensor. This electrical field-induced method is highly significant for the development and fabrication of LMR-based biosensors. MDPI 2021-03-18 /pmc/articles/PMC8003139/ /pubmed/33803880 http://dx.doi.org/10.3390/bios11030086 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Lin, Yu-Cheng
Chen, Liang-Yü
Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title_full Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title_fullStr Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title_full_unstemmed Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title_short Subtle Application of Electrical Field-Induced Lossy Mode Resonance to Enhance Performance of Optical Planar Waveguide Biosensor
title_sort subtle application of electrical field-induced lossy mode resonance to enhance performance of optical planar waveguide biosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003139/
https://www.ncbi.nlm.nih.gov/pubmed/33803880
http://dx.doi.org/10.3390/bios11030086
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