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Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases

Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to...

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Autores principales: Mussbacher, Marion, Brunnthaler, Laura, Panhuber, Anja, Starlinger, Patrick, Assinger, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003150/
https://www.ncbi.nlm.nih.gov/pubmed/33803718
http://dx.doi.org/10.3390/ijms22063113
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author Mussbacher, Marion
Brunnthaler, Laura
Panhuber, Anja
Starlinger, Patrick
Assinger, Alice
author_facet Mussbacher, Marion
Brunnthaler, Laura
Panhuber, Anja
Starlinger, Patrick
Assinger, Alice
author_sort Mussbacher, Marion
collection PubMed
description Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to liver regeneration. Due to their versatile functions, which include (1) regulation of hemostasis, (2) fine-tuning of immune responses and (3) release of growth factors and cellular mediators, platelets quickly adapt to environmental changes and modulate disease development, leading to different layers of complexity. Depending on the (patho)physiological context, platelets exert both beneficial and detrimental functions. Understanding the precise mechanisms through which platelet function is regulated at different stages of liver diseases and how platelets interact with various resident and non-resident liver cells helps to draw a clear picture of platelet-related therapeutic interventions. Therefore, this review summarizes the current knowledge on platelets in acute and chronic liver diseases and aims to shed light on how the smallest cells in the circulatory system account for changes in the (patho)physiology of the second largest organ in the human body.
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spelling pubmed-80031502021-03-28 Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases Mussbacher, Marion Brunnthaler, Laura Panhuber, Anja Starlinger, Patrick Assinger, Alice Int J Mol Sci Review Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to liver regeneration. Due to their versatile functions, which include (1) regulation of hemostasis, (2) fine-tuning of immune responses and (3) release of growth factors and cellular mediators, platelets quickly adapt to environmental changes and modulate disease development, leading to different layers of complexity. Depending on the (patho)physiological context, platelets exert both beneficial and detrimental functions. Understanding the precise mechanisms through which platelet function is regulated at different stages of liver diseases and how platelets interact with various resident and non-resident liver cells helps to draw a clear picture of platelet-related therapeutic interventions. Therefore, this review summarizes the current knowledge on platelets in acute and chronic liver diseases and aims to shed light on how the smallest cells in the circulatory system account for changes in the (patho)physiology of the second largest organ in the human body. MDPI 2021-03-18 /pmc/articles/PMC8003150/ /pubmed/33803718 http://dx.doi.org/10.3390/ijms22063113 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mussbacher, Marion
Brunnthaler, Laura
Panhuber, Anja
Starlinger, Patrick
Assinger, Alice
Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title_full Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title_fullStr Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title_full_unstemmed Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title_short Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
title_sort till death do us part—the multifaceted role of platelets in liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003150/
https://www.ncbi.nlm.nih.gov/pubmed/33803718
http://dx.doi.org/10.3390/ijms22063113
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