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Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003150/ https://www.ncbi.nlm.nih.gov/pubmed/33803718 http://dx.doi.org/10.3390/ijms22063113 |
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author | Mussbacher, Marion Brunnthaler, Laura Panhuber, Anja Starlinger, Patrick Assinger, Alice |
author_facet | Mussbacher, Marion Brunnthaler, Laura Panhuber, Anja Starlinger, Patrick Assinger, Alice |
author_sort | Mussbacher, Marion |
collection | PubMed |
description | Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to liver regeneration. Due to their versatile functions, which include (1) regulation of hemostasis, (2) fine-tuning of immune responses and (3) release of growth factors and cellular mediators, platelets quickly adapt to environmental changes and modulate disease development, leading to different layers of complexity. Depending on the (patho)physiological context, platelets exert both beneficial and detrimental functions. Understanding the precise mechanisms through which platelet function is regulated at different stages of liver diseases and how platelets interact with various resident and non-resident liver cells helps to draw a clear picture of platelet-related therapeutic interventions. Therefore, this review summarizes the current knowledge on platelets in acute and chronic liver diseases and aims to shed light on how the smallest cells in the circulatory system account for changes in the (patho)physiology of the second largest organ in the human body. |
format | Online Article Text |
id | pubmed-8003150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80031502021-03-28 Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases Mussbacher, Marion Brunnthaler, Laura Panhuber, Anja Starlinger, Patrick Assinger, Alice Int J Mol Sci Review Platelets are tightly connected with the liver, as both their production and their clearance are mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging from non-alcoholic fatty liver diseases, (viral) hepatitis, liver fibrosis and hepatocellular carcinoma to liver regeneration. Due to their versatile functions, which include (1) regulation of hemostasis, (2) fine-tuning of immune responses and (3) release of growth factors and cellular mediators, platelets quickly adapt to environmental changes and modulate disease development, leading to different layers of complexity. Depending on the (patho)physiological context, platelets exert both beneficial and detrimental functions. Understanding the precise mechanisms through which platelet function is regulated at different stages of liver diseases and how platelets interact with various resident and non-resident liver cells helps to draw a clear picture of platelet-related therapeutic interventions. Therefore, this review summarizes the current knowledge on platelets in acute and chronic liver diseases and aims to shed light on how the smallest cells in the circulatory system account for changes in the (patho)physiology of the second largest organ in the human body. MDPI 2021-03-18 /pmc/articles/PMC8003150/ /pubmed/33803718 http://dx.doi.org/10.3390/ijms22063113 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mussbacher, Marion Brunnthaler, Laura Panhuber, Anja Starlinger, Patrick Assinger, Alice Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title | Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title_full | Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title_fullStr | Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title_full_unstemmed | Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title_short | Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases |
title_sort | till death do us part—the multifaceted role of platelets in liver diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003150/ https://www.ncbi.nlm.nih.gov/pubmed/33803718 http://dx.doi.org/10.3390/ijms22063113 |
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