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Real-Time Positron Emission Tomography Evaluation of Topotecan Brain Kinetics after Ultrasound-Mediated Blood–Brain Barrier Permeability

Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely poor prognosis and a median survival of fewer than two years. A key reason for this high mortality is that the blood–brain barrier (BBB) significantly restricts systemically delivered therapeutics to brain tumors....

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Detalles Bibliográficos
Autores principales:	Molotkov, Andrei, Carberry, Patrick, Dolan, Martin A., Joseph, Simon, Idumonyi, Sidney, Oya, Shunichi, Castrillon, John, Konofagou, Elisa E., Doubrovin, Mikhail, Lesser, Glenn J., Zanderigo, Francesca, Mintz, Akiva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003157/ https://www.ncbi.nlm.nih.gov/pubmed/33803856 http://dx.doi.org/10.3390/pharmaceutics13030405

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