Cargando…

Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases

Endosome-derived small extracellular vesicles (EVs), often referred to as exosomes, are produced by almost all, if not all, cell types, and are critical for intercellular communication. They are composed of a lipid bilayer associated with membrane proteins and contain a payload of lipids, proteins a...

Descripción completa

Detalles Bibliográficos
Autores principales: Manchon, Enzo, Hirt, Nell, Bouaziz, Jean-David, Jabrane-Ferrat, Nabila, Al-Daccak, Reem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003197/
https://www.ncbi.nlm.nih.gov/pubmed/33808520
http://dx.doi.org/10.3390/ijms22063130
_version_ 1783671633216536576
author Manchon, Enzo
Hirt, Nell
Bouaziz, Jean-David
Jabrane-Ferrat, Nabila
Al-Daccak, Reem
author_facet Manchon, Enzo
Hirt, Nell
Bouaziz, Jean-David
Jabrane-Ferrat, Nabila
Al-Daccak, Reem
author_sort Manchon, Enzo
collection PubMed
description Endosome-derived small extracellular vesicles (EVs), often referred to as exosomes, are produced by almost all, if not all, cell types, and are critical for intercellular communication. They are composed of a lipid bilayer associated with membrane proteins and contain a payload of lipids, proteins and regulatory RNAs that depends on the parental cell physiological condition. By transferring their “cargo”, exosomes can modulate the phenotype of neighboring and distant cells. Stem cells (SC) were widely studied for therapeutic applications regarding their regenerative/reparative potential as well as their immunomodulatory properties. Whether from autologous or allogeneic source, SC beneficial effects in terms of repair and regeneration are largely attributed to their paracrine signaling notably through secreted EVs. Subsequently, SC-derived EVs have been investigated for the treatment of various diseases, including inflammatory skin disorders, and are today fast-track cell-free tools for regenerative/reparative strategies. Yet, their clinical application is still facing considerable challenges, including production and isolation procedures, and optimal cell source. Within the emerging concept of “allogeneic-driven benefit” for SC-based therapies, the use of EVs from allogeneic sources becomes the pragmatic choice although a universal allogeneic cell source is still needed. As a unique temporary organ that ensures the mutual coexistence of two allogeneic organisms, mother and fetus, the human placenta offers a persuasive allogeneic stem cell source for development of therapeutic EVs. Advancing cell-free therapeutics nurtures great hope and provides new perspectives for the development of safe and effective treatment in regenerative/reparative medicine and beyond. We will outline the current state of the art in regard of EVs, summarize their therapeutic potential in the context of skin inflammatory disorders, and discuss their translational advantages and hurdles.
format Online
Article
Text
id pubmed-8003197
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80031972021-03-28 Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases Manchon, Enzo Hirt, Nell Bouaziz, Jean-David Jabrane-Ferrat, Nabila Al-Daccak, Reem Int J Mol Sci Review Endosome-derived small extracellular vesicles (EVs), often referred to as exosomes, are produced by almost all, if not all, cell types, and are critical for intercellular communication. They are composed of a lipid bilayer associated with membrane proteins and contain a payload of lipids, proteins and regulatory RNAs that depends on the parental cell physiological condition. By transferring their “cargo”, exosomes can modulate the phenotype of neighboring and distant cells. Stem cells (SC) were widely studied for therapeutic applications regarding their regenerative/reparative potential as well as their immunomodulatory properties. Whether from autologous or allogeneic source, SC beneficial effects in terms of repair and regeneration are largely attributed to their paracrine signaling notably through secreted EVs. Subsequently, SC-derived EVs have been investigated for the treatment of various diseases, including inflammatory skin disorders, and are today fast-track cell-free tools for regenerative/reparative strategies. Yet, their clinical application is still facing considerable challenges, including production and isolation procedures, and optimal cell source. Within the emerging concept of “allogeneic-driven benefit” for SC-based therapies, the use of EVs from allogeneic sources becomes the pragmatic choice although a universal allogeneic cell source is still needed. As a unique temporary organ that ensures the mutual coexistence of two allogeneic organisms, mother and fetus, the human placenta offers a persuasive allogeneic stem cell source for development of therapeutic EVs. Advancing cell-free therapeutics nurtures great hope and provides new perspectives for the development of safe and effective treatment in regenerative/reparative medicine and beyond. We will outline the current state of the art in regard of EVs, summarize their therapeutic potential in the context of skin inflammatory disorders, and discuss their translational advantages and hurdles. MDPI 2021-03-19 /pmc/articles/PMC8003197/ /pubmed/33808520 http://dx.doi.org/10.3390/ijms22063130 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manchon, Enzo
Hirt, Nell
Bouaziz, Jean-David
Jabrane-Ferrat, Nabila
Al-Daccak, Reem
Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title_full Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title_fullStr Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title_full_unstemmed Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title_short Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
title_sort stem cells-derived extracellular vesicles: potential therapeutics for wound healing in chronic inflammatory skin diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003197/
https://www.ncbi.nlm.nih.gov/pubmed/33808520
http://dx.doi.org/10.3390/ijms22063130
work_keys_str_mv AT manchonenzo stemcellsderivedextracellularvesiclespotentialtherapeuticsforwoundhealinginchronicinflammatoryskindiseases
AT hirtnell stemcellsderivedextracellularvesiclespotentialtherapeuticsforwoundhealinginchronicinflammatoryskindiseases
AT bouazizjeandavid stemcellsderivedextracellularvesiclespotentialtherapeuticsforwoundhealinginchronicinflammatoryskindiseases
AT jabraneferratnabila stemcellsderivedextracellularvesiclespotentialtherapeuticsforwoundhealinginchronicinflammatoryskindiseases
AT aldaccakreem stemcellsderivedextracellularvesiclespotentialtherapeuticsforwoundhealinginchronicinflammatoryskindiseases