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Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive numb...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003266/ https://www.ncbi.nlm.nih.gov/pubmed/33803907 http://dx.doi.org/10.3390/ijms22063128 |
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author | Jurado-Martín, Irene Sainz-Mejías, Maite McClean, Siobhán |
author_facet | Jurado-Martín, Irene Sainz-Mejías, Maite McClean, Siobhán |
author_sort | Jurado-Martín, Irene |
collection | PubMed |
description | Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. aeruginosa with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating P. aeruginosa evolution and its interactions with the host throughout the course of infection. |
format | Online Article Text |
id | pubmed-8003266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80032662021-03-28 Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors Jurado-Martín, Irene Sainz-Mejías, Maite McClean, Siobhán Int J Mol Sci Review Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. aeruginosa with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating P. aeruginosa evolution and its interactions with the host throughout the course of infection. MDPI 2021-03-18 /pmc/articles/PMC8003266/ /pubmed/33803907 http://dx.doi.org/10.3390/ijms22063128 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jurado-Martín, Irene Sainz-Mejías, Maite McClean, Siobhán Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title | Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title_full | Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title_fullStr | Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title_full_unstemmed | Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title_short | Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors |
title_sort | pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003266/ https://www.ncbi.nlm.nih.gov/pubmed/33803907 http://dx.doi.org/10.3390/ijms22063128 |
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