Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry

Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety...

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Detalles Bibliográficos
Autores principales: Choi, Hyunsik, Kwon, Mina, Choi, Hye Eun, Hahn, Sei Kwang, Kim, Ki Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003300/
https://www.ncbi.nlm.nih.gov/pubmed/33803897
http://dx.doi.org/10.3390/ma14061504
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author Choi, Hyunsik
Kwon, Mina
Choi, Hye Eun
Hahn, Sei Kwang
Kim, Ki Su
author_facet Choi, Hyunsik
Kwon, Mina
Choi, Hye Eun
Hahn, Sei Kwang
Kim, Ki Su
author_sort Choi, Hyunsik
collection PubMed
description Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs.
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spelling pubmed-80033002021-03-28 Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry Choi, Hyunsik Kwon, Mina Choi, Hye Eun Hahn, Sei Kwang Kim, Ki Su Materials (Basel) Communication Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs. MDPI 2021-03-18 /pmc/articles/PMC8003300/ /pubmed/33803897 http://dx.doi.org/10.3390/ma14061504 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Choi, Hyunsik
Kwon, Mina
Choi, Hye Eun
Hahn, Sei Kwang
Kim, Ki Su
Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title_full Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title_fullStr Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title_full_unstemmed Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title_short Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
title_sort non-invasive topical drug-delivery system using hyaluronate nanogels crosslinked via click chemistry
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003300/
https://www.ncbi.nlm.nih.gov/pubmed/33803897
http://dx.doi.org/10.3390/ma14061504
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