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The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy
Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory ne...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003358/ https://www.ncbi.nlm.nih.gov/pubmed/33808762 http://dx.doi.org/10.3390/ijms22063149 |
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author | Kim, Hye Yun Suh, Pann-Ghill Kim, Jae-Ick |
author_facet | Kim, Hye Yun Suh, Pann-Ghill Kim, Jae-Ick |
author_sort | Kim, Hye Yun |
collection | PubMed |
description | Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory neurotransmitter and plays a pivotal role in maintaining E/I balance. As such, altered GABAergic inhibition can lead to severe E/I imbalance, consequently resulting in excessive and hypersynchronous neuronal activity as in epilepsy. Phospholipase C (PLC) is a key enzyme in the intracellular signaling pathway and regulates various neuronal functions including neuronal development, synaptic transmission, and plasticity in the brain. Accumulating evidence suggests that neuronal PLC is critically involved in multiple aspects of GABAergic functions. Therefore, a better understanding of mechanisms by which neuronal PLC regulates GABAergic inhibition is necessary for revealing an unrecognized linkage between PLC and epilepsy and developing more effective treatments for epilepsy. Here we review the function of PLC in GABAergic inhibition in the brain and discuss a pathophysiological relationship between PLC and epilepsy. |
format | Online Article Text |
id | pubmed-8003358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80033582021-03-28 The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy Kim, Hye Yun Suh, Pann-Ghill Kim, Jae-Ick Int J Mol Sci Review Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory neurotransmitter and plays a pivotal role in maintaining E/I balance. As such, altered GABAergic inhibition can lead to severe E/I imbalance, consequently resulting in excessive and hypersynchronous neuronal activity as in epilepsy. Phospholipase C (PLC) is a key enzyme in the intracellular signaling pathway and regulates various neuronal functions including neuronal development, synaptic transmission, and plasticity in the brain. Accumulating evidence suggests that neuronal PLC is critically involved in multiple aspects of GABAergic functions. Therefore, a better understanding of mechanisms by which neuronal PLC regulates GABAergic inhibition is necessary for revealing an unrecognized linkage between PLC and epilepsy and developing more effective treatments for epilepsy. Here we review the function of PLC in GABAergic inhibition in the brain and discuss a pathophysiological relationship between PLC and epilepsy. MDPI 2021-03-19 /pmc/articles/PMC8003358/ /pubmed/33808762 http://dx.doi.org/10.3390/ijms22063149 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Hye Yun Suh, Pann-Ghill Kim, Jae-Ick The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title | The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title_full | The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title_fullStr | The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title_full_unstemmed | The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title_short | The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy |
title_sort | role of phospholipase c in gabaergic inhibition and its relevance to epilepsy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003358/ https://www.ncbi.nlm.nih.gov/pubmed/33808762 http://dx.doi.org/10.3390/ijms22063149 |
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