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Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs

Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregn...

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Autores principales: Pankiewicz, Katarzyna, Fijałkowska, Anna, Issat, Tadeusz, Maciejewski, Tomasz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003365/
https://www.ncbi.nlm.nih.gov/pubmed/33808559
http://dx.doi.org/10.3390/ijms22063132
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author Pankiewicz, Katarzyna
Fijałkowska, Anna
Issat, Tadeusz
Maciejewski, Tomasz M.
author_facet Pankiewicz, Katarzyna
Fijałkowska, Anna
Issat, Tadeusz
Maciejewski, Tomasz M.
author_sort Pankiewicz, Katarzyna
collection PubMed
description Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregnancy and is thought to be impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries that leads to reduced placental perfusion and release of numerous biological factors causing endothelial damage and development of acute maternal syndrome with systemic multiorgan failure (stage 2—the onset of maternal clinical symptoms, maternal stage). Recently, in the light of the vast body of evidence, two-stage model of preeclampsia has been updated with a few novel pathways leading to clinical manifestation in the second part of pregnancy. This paper reviews current state of knowledge about pathophysiology of preeclampsia and places particular focus on the recent advances in understanding of uterine artery remodeling alterations, as well as the role of microRNAs in preeclampsia.
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spelling pubmed-80033652021-03-28 Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs Pankiewicz, Katarzyna Fijałkowska, Anna Issat, Tadeusz Maciejewski, Tomasz M. Int J Mol Sci Review Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregnancy and is thought to be impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries that leads to reduced placental perfusion and release of numerous biological factors causing endothelial damage and development of acute maternal syndrome with systemic multiorgan failure (stage 2—the onset of maternal clinical symptoms, maternal stage). Recently, in the light of the vast body of evidence, two-stage model of preeclampsia has been updated with a few novel pathways leading to clinical manifestation in the second part of pregnancy. This paper reviews current state of knowledge about pathophysiology of preeclampsia and places particular focus on the recent advances in understanding of uterine artery remodeling alterations, as well as the role of microRNAs in preeclampsia. MDPI 2021-03-19 /pmc/articles/PMC8003365/ /pubmed/33808559 http://dx.doi.org/10.3390/ijms22063132 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pankiewicz, Katarzyna
Fijałkowska, Anna
Issat, Tadeusz
Maciejewski, Tomasz M.
Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title_full Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title_fullStr Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title_full_unstemmed Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title_short Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs
title_sort insight into the key points of preeclampsia pathophysiology: uterine artery remodeling and the role of micrornas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003365/
https://www.ncbi.nlm.nih.gov/pubmed/33808559
http://dx.doi.org/10.3390/ijms22063132
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