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Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study
Background and Objectives: Despite advances in treatment, local recurrence remains a great concern in patients with rectal cancer. The aim of this study was to investigate the incidence and risk factors of local recurrence of rectal cancer in our single center over a 7-year-period. Materials and Met...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003449/ https://www.ncbi.nlm.nih.gov/pubmed/33808603 http://dx.doi.org/10.3390/medicina57030286 |
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author | Jankowski, Michał Las-Jankowska, Manuela Rutkowski, Andrzej Bała, Dariusz Wiśniewski, Dorian Tkaczyński, Karol Kowalski, Witold Głowacka-Mrotek, Iwona Zegarski, Wojciech |
author_facet | Jankowski, Michał Las-Jankowska, Manuela Rutkowski, Andrzej Bała, Dariusz Wiśniewski, Dorian Tkaczyński, Karol Kowalski, Witold Głowacka-Mrotek, Iwona Zegarski, Wojciech |
author_sort | Jankowski, Michał |
collection | PubMed |
description | Background and Objectives: Despite advances in treatment, local recurrence remains a great concern in patients with rectal cancer. The aim of this study was to investigate the incidence and risk factors of local recurrence of rectal cancer in our single center over a 7-year-period. Materials and Methods: Patients with stage I-III rectal cancer were treated with curative intent. The necessity for radiotherapy and chemotherapy was determined before surgery and/or postoperative histopathological results. Results: Of 365 rectal cancer patients, 76 (20.8%) developed recurrent disease. In total, 27 (7.4%) patients presented with a local tumor recurrence (isolated in 40.7% of cases). Radiotherapy was performed in 296 (81.1%) patients. The most often used schema was 5 × 5 Gy followed by immediate surgery (n = 214, 58.6%). Local recurrence occurred less frequently in patients treated with 5 × 5 Gy radiotherapy followed by surgery (n = 9, 4%). Surgical procedures of relapses were performed in 12 patients, six of whom were operated with radical intent. Only two (7.4%) patients lived more than 5 years after local recurrence treatment. The incidence of local recurrence was associated with primary tumor distal location and worse prognosis. The median overall survival of patients after local recurrence treatment was 19 months. Conclusions: Individualized rectal cancer patient selection and systematic treatment algorithms should be used clinical practice to minimize likelihood of relapse. 5 × 5 Gy radiotherapy followed by immediate surgery allows good local control in resectable cT2N+/cT3N0 patients. Radical resection of isolated local recurrence offers the best chances of cure. |
format | Online Article Text |
id | pubmed-8003449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80034492021-03-28 Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study Jankowski, Michał Las-Jankowska, Manuela Rutkowski, Andrzej Bała, Dariusz Wiśniewski, Dorian Tkaczyński, Karol Kowalski, Witold Głowacka-Mrotek, Iwona Zegarski, Wojciech Medicina (Kaunas) Article Background and Objectives: Despite advances in treatment, local recurrence remains a great concern in patients with rectal cancer. The aim of this study was to investigate the incidence and risk factors of local recurrence of rectal cancer in our single center over a 7-year-period. Materials and Methods: Patients with stage I-III rectal cancer were treated with curative intent. The necessity for radiotherapy and chemotherapy was determined before surgery and/or postoperative histopathological results. Results: Of 365 rectal cancer patients, 76 (20.8%) developed recurrent disease. In total, 27 (7.4%) patients presented with a local tumor recurrence (isolated in 40.7% of cases). Radiotherapy was performed in 296 (81.1%) patients. The most often used schema was 5 × 5 Gy followed by immediate surgery (n = 214, 58.6%). Local recurrence occurred less frequently in patients treated with 5 × 5 Gy radiotherapy followed by surgery (n = 9, 4%). Surgical procedures of relapses were performed in 12 patients, six of whom were operated with radical intent. Only two (7.4%) patients lived more than 5 years after local recurrence treatment. The incidence of local recurrence was associated with primary tumor distal location and worse prognosis. The median overall survival of patients after local recurrence treatment was 19 months. Conclusions: Individualized rectal cancer patient selection and systematic treatment algorithms should be used clinical practice to minimize likelihood of relapse. 5 × 5 Gy radiotherapy followed by immediate surgery allows good local control in resectable cT2N+/cT3N0 patients. Radical resection of isolated local recurrence offers the best chances of cure. MDPI 2021-03-19 /pmc/articles/PMC8003449/ /pubmed/33808603 http://dx.doi.org/10.3390/medicina57030286 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Jankowski, Michał Las-Jankowska, Manuela Rutkowski, Andrzej Bała, Dariusz Wiśniewski, Dorian Tkaczyński, Karol Kowalski, Witold Głowacka-Mrotek, Iwona Zegarski, Wojciech Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title | Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title_full | Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title_fullStr | Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title_full_unstemmed | Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title_short | Clinical Reality and Treatment for Local Recurrence of Rectal Cancer: A Single-Center Retrospective Study |
title_sort | clinical reality and treatment for local recurrence of rectal cancer: a single-center retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003449/ https://www.ncbi.nlm.nih.gov/pubmed/33808603 http://dx.doi.org/10.3390/medicina57030286 |
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