Non-Coding RNAs as Prognostic Markers for Endometrial Cancer

Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are...

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Detalles Bibliográficos
Autores principales: Piergentili, Roberto, Zaami, Simona, Cavaliere, Anna Franca, Signore, Fabrizio, Scambia, Giovanni, Mattei, Alberto, Marinelli, Enrico, Gulia, Caterina, Perelli, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003471/
https://www.ncbi.nlm.nih.gov/pubmed/33808791
http://dx.doi.org/10.3390/ijms22063151
Descripción
Sumario:Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are emerging as promising markers in several cancer types, including EC, for which their prognostic value is currently under investigation and will likely integrate the present prognostic tools based on protein coding genes. This review aims to underline the importance of the genetic and epigenetic events in the EC tumorigenesis, by expounding upon the prognostic role of ncRNAs.

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