The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer

N6-methyladenosine (m(6)A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m(6)A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m(6)A methyltransferases, demethylases and m(6)A-binding proteins, and this modification pl...

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Autores principales: Cheng, Yue, Wang, Meiqi, Zhou, Junliang, Dong, Huanhuan, Wang, Shuqing, Xu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003501/
https://www.ncbi.nlm.nih.gov/pubmed/33808751
http://dx.doi.org/10.3390/genes12030440
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author Cheng, Yue
Wang, Meiqi
Zhou, Junliang
Dong, Huanhuan
Wang, Shuqing
Xu, Hui
author_facet Cheng, Yue
Wang, Meiqi
Zhou, Junliang
Dong, Huanhuan
Wang, Shuqing
Xu, Hui
author_sort Cheng, Yue
collection PubMed
description N6-methyladenosine (m(6)A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m(6)A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m(6)A methyltransferases, demethylases and m(6)A-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the m(6)A modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various m(6)A regulators modulate m(6)A RNA metabolism and demonstrated the effect of m(6)A modification on the progression and cellular biological functions of NSCLC. We also discussed how m(6)A modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients.
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spelling pubmed-80035012021-03-28 The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer Cheng, Yue Wang, Meiqi Zhou, Junliang Dong, Huanhuan Wang, Shuqing Xu, Hui Genes (Basel) Review N6-methyladenosine (m(6)A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m(6)A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m(6)A methyltransferases, demethylases and m(6)A-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the m(6)A modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various m(6)A regulators modulate m(6)A RNA metabolism and demonstrated the effect of m(6)A modification on the progression and cellular biological functions of NSCLC. We also discussed how m(6)A modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients. MDPI 2021-03-19 /pmc/articles/PMC8003501/ /pubmed/33808751 http://dx.doi.org/10.3390/genes12030440 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Cheng, Yue
Wang, Meiqi
Zhou, Junliang
Dong, Huanhuan
Wang, Shuqing
Xu, Hui
The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title_full The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title_fullStr The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title_full_unstemmed The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title_short The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
title_sort important role of n6-methyladenosine rna modification in non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003501/
https://www.ncbi.nlm.nih.gov/pubmed/33808751
http://dx.doi.org/10.3390/genes12030440
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