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Total Laryngectomy—Still Cutting-Edge?

SIMPLE SUMMARY: Complete removal of the larynx (total laryngectomy) offers a curative approach for advanced laryngeal and pharyngeal cancer. If the operation is performed after radiotherapy wound healing problems have to be taken into account which can be managed by adapted reconstructive techniques...

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Detalles Bibliográficos
Autor principal: Hoffmann, Thomas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003522/
https://www.ncbi.nlm.nih.gov/pubmed/33808695
http://dx.doi.org/10.3390/cancers13061405
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author Hoffmann, Thomas K.
author_facet Hoffmann, Thomas K.
author_sort Hoffmann, Thomas K.
collection PubMed
description SIMPLE SUMMARY: Complete removal of the larynx (total laryngectomy) offers a curative approach for advanced laryngeal and pharyngeal cancer. If the operation is performed after radiotherapy wound healing problems have to be taken into account which can be managed by adapted reconstructive techniques. Laryngectomy results in the loss of voice which can be managed e.g., by using a voice prosthesis with a significant increase in quality of life. Total laryngectomy still represents a relevant surgical procedure in modern head and neck oncology. ABSTRACT: Surgical removal of the larynx (total laryngectomy) offers a curative approach to patients with advanced laryngeal and hypopharyngeal (squamous cell) cancer without distant metastases. Particularly in T4a carcinoma, laryngectomy seems prognostically superior to primary radio(chemo)therapy. Further relevant indications for laryngectomy include massive laryngeal dysfunction associated with aspiration and recurrence after radio(chemo)therapy, resulting in salvage surgery. The surgical procedure including neck dissection is highly standardised and safe. The resulting aphonia can be compensated by functional rehabilitation (e.g., voice prosthesis) associated with a significant quality of life improvement. This article presents an overview of indications, preoperative diagnostics, surgical procedures, including new developments (robotics), possible complications, the choice of adjuvant treatment, alternative therapeutic approaches, rehabilitation and prognosis. In summary, total laryngectomy still represents a relevant surgical procedure in modern head and neck oncology.
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spelling pubmed-80035222021-03-28 Total Laryngectomy—Still Cutting-Edge? Hoffmann, Thomas K. Cancers (Basel) Review SIMPLE SUMMARY: Complete removal of the larynx (total laryngectomy) offers a curative approach for advanced laryngeal and pharyngeal cancer. If the operation is performed after radiotherapy wound healing problems have to be taken into account which can be managed by adapted reconstructive techniques. Laryngectomy results in the loss of voice which can be managed e.g., by using a voice prosthesis with a significant increase in quality of life. Total laryngectomy still represents a relevant surgical procedure in modern head and neck oncology. ABSTRACT: Surgical removal of the larynx (total laryngectomy) offers a curative approach to patients with advanced laryngeal and hypopharyngeal (squamous cell) cancer without distant metastases. Particularly in T4a carcinoma, laryngectomy seems prognostically superior to primary radio(chemo)therapy. Further relevant indications for laryngectomy include massive laryngeal dysfunction associated with aspiration and recurrence after radio(chemo)therapy, resulting in salvage surgery. The surgical procedure including neck dissection is highly standardised and safe. The resulting aphonia can be compensated by functional rehabilitation (e.g., voice prosthesis) associated with a significant quality of life improvement. This article presents an overview of indications, preoperative diagnostics, surgical procedures, including new developments (robotics), possible complications, the choice of adjuvant treatment, alternative therapeutic approaches, rehabilitation and prognosis. In summary, total laryngectomy still represents a relevant surgical procedure in modern head and neck oncology. MDPI 2021-03-19 /pmc/articles/PMC8003522/ /pubmed/33808695 http://dx.doi.org/10.3390/cancers13061405 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hoffmann, Thomas K.
Total Laryngectomy—Still Cutting-Edge?
title Total Laryngectomy—Still Cutting-Edge?
title_full Total Laryngectomy—Still Cutting-Edge?
title_fullStr Total Laryngectomy—Still Cutting-Edge?
title_full_unstemmed Total Laryngectomy—Still Cutting-Edge?
title_short Total Laryngectomy—Still Cutting-Edge?
title_sort total laryngectomy—still cutting-edge?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003522/
https://www.ncbi.nlm.nih.gov/pubmed/33808695
http://dx.doi.org/10.3390/cancers13061405
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