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Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery

Polyunsaturated fatty acids (PUFAs) are essential for fetal development, and intrauterine transfer is the only supply of PUFAs to the fetus. The prevailing theory of gestational nutrient transfer is that certain nutrients (including PUFAs) may have prioritized transport across the placenta. Numerous...

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Autores principales: Woodard, Vanessa, Thoene, Melissa, Van Ormer, Matthew, Thompson, Maranda, Hanson, Corrine, Natarajan, Sathish Kumar, Mukherjee, Maheswari, Yuil-Valdes, Ana, Nordgren, Tara M., Ulu, Arzu, Harris Jackson, Kristina, Anderson-Berry, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003544/
https://www.ncbi.nlm.nih.gov/pubmed/33808763
http://dx.doi.org/10.3390/nu13030996
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author Woodard, Vanessa
Thoene, Melissa
Van Ormer, Matthew
Thompson, Maranda
Hanson, Corrine
Natarajan, Sathish Kumar
Mukherjee, Maheswari
Yuil-Valdes, Ana
Nordgren, Tara M.
Ulu, Arzu
Harris Jackson, Kristina
Anderson-Berry, Ann
author_facet Woodard, Vanessa
Thoene, Melissa
Van Ormer, Matthew
Thompson, Maranda
Hanson, Corrine
Natarajan, Sathish Kumar
Mukherjee, Maheswari
Yuil-Valdes, Ana
Nordgren, Tara M.
Ulu, Arzu
Harris Jackson, Kristina
Anderson-Berry, Ann
author_sort Woodard, Vanessa
collection PubMed
description Polyunsaturated fatty acids (PUFAs) are essential for fetal development, and intrauterine transfer is the only supply of PUFAs to the fetus. The prevailing theory of gestational nutrient transfer is that certain nutrients (including PUFAs) may have prioritized transport across the placenta. Numerous studies have identified correlations between maternal and infant fatty acid concentrations; however, little is known about what role maternal PUFA status may play in differential intrauterine nutrient transfer. Twenty mother–infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood, and placental tissue samples. Plasma concentrations of PUFAs were assessed using gas chromatography (GC-FID). Intrauterine transfer percentages for each fatty acid were calculated as follows: ((cord blood fatty acid level/maternal blood fatty acid level) × 100). Kruskal–Wallis tests were used to compare transfer percentages between maternal fatty acid tertile groups. A p-value < 0.05 was considered significant. There were statistically significant differences in intrauterine transfer percentages of arachidonic acid (AA) (64% vs. 65% vs. 45%, p = 0.02), eicosapentaenoic acid (EPA) (41% vs. 19% vs. 17%, p = 0.03), and total fatty acids (TFA) (27% vs. 26% vs. 20%, p = 0.05) between maternal plasma fatty acid tertiles. Intrauterine transfer percentages of AA, EPA, and TFA were highest in the lowest tertile of respective maternal fatty acid concentration. These findings may indicate that fatty acid transfer to the fetus is prioritized during gestation even during periods of maternal nutritional inadequacy.
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spelling pubmed-80035442021-03-28 Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery Woodard, Vanessa Thoene, Melissa Van Ormer, Matthew Thompson, Maranda Hanson, Corrine Natarajan, Sathish Kumar Mukherjee, Maheswari Yuil-Valdes, Ana Nordgren, Tara M. Ulu, Arzu Harris Jackson, Kristina Anderson-Berry, Ann Nutrients Article Polyunsaturated fatty acids (PUFAs) are essential for fetal development, and intrauterine transfer is the only supply of PUFAs to the fetus. The prevailing theory of gestational nutrient transfer is that certain nutrients (including PUFAs) may have prioritized transport across the placenta. Numerous studies have identified correlations between maternal and infant fatty acid concentrations; however, little is known about what role maternal PUFA status may play in differential intrauterine nutrient transfer. Twenty mother–infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood, and placental tissue samples. Plasma concentrations of PUFAs were assessed using gas chromatography (GC-FID). Intrauterine transfer percentages for each fatty acid were calculated as follows: ((cord blood fatty acid level/maternal blood fatty acid level) × 100). Kruskal–Wallis tests were used to compare transfer percentages between maternal fatty acid tertile groups. A p-value < 0.05 was considered significant. There were statistically significant differences in intrauterine transfer percentages of arachidonic acid (AA) (64% vs. 65% vs. 45%, p = 0.02), eicosapentaenoic acid (EPA) (41% vs. 19% vs. 17%, p = 0.03), and total fatty acids (TFA) (27% vs. 26% vs. 20%, p = 0.05) between maternal plasma fatty acid tertiles. Intrauterine transfer percentages of AA, EPA, and TFA were highest in the lowest tertile of respective maternal fatty acid concentration. These findings may indicate that fatty acid transfer to the fetus is prioritized during gestation even during periods of maternal nutritional inadequacy. MDPI 2021-03-19 /pmc/articles/PMC8003544/ /pubmed/33808763 http://dx.doi.org/10.3390/nu13030996 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Woodard, Vanessa
Thoene, Melissa
Van Ormer, Matthew
Thompson, Maranda
Hanson, Corrine
Natarajan, Sathish Kumar
Mukherjee, Maheswari
Yuil-Valdes, Ana
Nordgren, Tara M.
Ulu, Arzu
Harris Jackson, Kristina
Anderson-Berry, Ann
Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title_full Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title_fullStr Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title_full_unstemmed Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title_short Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
title_sort intrauterine transfer of polyunsaturated fatty acids in mother–infant dyads as analyzed at time of delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003544/
https://www.ncbi.nlm.nih.gov/pubmed/33808763
http://dx.doi.org/10.3390/nu13030996
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