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Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently based on recruitment of either intracellular m...
Autores principales: | Staroseletz, Yaroslav, Gaponova, Svetlana, Patutina, Olga, Bichenkova, Elena, Amirloo, Bahareh, Heyman, Thomas, Chiglintseva, Daria, Zenkova, Marina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003597/ https://www.ncbi.nlm.nih.gov/pubmed/33808835 http://dx.doi.org/10.3390/molecules26061732 |
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