Cargando…

Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors

A series of azastilbene derivatives, characterized by the presence of the 1,2,4-oxadiazole-5-one system as a linker of the two aromatic rings of stilbenes, have been prepared as novel potential inhibitors of p38 MAPK. Biological assays indicated that some of the synthesized compounds are endowed wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romeo, Roberto, Giofrè, Salvatore V., Chiacchio, Maria A., Veltri, Lucia, Celesti, Consuelo, Iannazzo, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003627/ https://www.ncbi.nlm.nih.gov/pubmed/33804659 http://dx.doi.org/10.3390/molecules26061745

Ejemplares similares

Chemoselective Oxidation of Isoxazolidines with Ruthenium Tetroxide: A Successful Intertwining of Combined Theoretical and Experimental Data
por: Legnani, Laura, et al.
Publicado: (2022)

Theranostic Applications of 2D Graphene-Based Materials for Solid Tumors Treatment
por: Iannazzo, Daniela, et al.
Publicado: (2023)

Reactions of 1,2,4‐Oxadiazole[4,5‐a]piridinium Salts with Alcohols: the Synthesis of Alkoxybutadienyl 1,2,4‐Oxadiazoles
por: Moiola, Mattia, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Pyrimidine-oxazolidin-2-arylimino Hybrid Molecules as Antibacterial Agents
por: Romeo, Roberto, et al.
Publicado: (2018)

Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors
por: Romeo, Roberto, et al.
Publicado: (2019)

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties
por: Pistone, Alessandro, et al.
Publicado: (2020)

Electrocyclic Ring‐Opening of 1,2,4‐Oxadiazole[4,5‐a]piridinium Chloride: a New Route to 1,2,4‐Oxadiazole Dienamino Compounds
por: Carella, Stefano, et al.
Publicado: (2019)

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
por: Biernacki, Karol, et al.
Publicado: (2020)

Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles †
por: Baykov, Sergey V., et al.
Publicado: (2023)

Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: synthesis, computational and biological studies
por: Legnani, Laura, et al.
Publicado: (2020)

New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity
por: Cascioferro, Stella, et al.
Publicado: (2019)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
por: Wang, Jing-Jing, et al.
Publicado: (2022)

3-(2,4-Dichlorophenyl)-5-methyl-1,2,4-oxadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

3-(2,4-Dichlorophenyl)-5-phenyl-1,2,4-oxadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation
por: Romeo, Roberto, et al.
Publicado: (2015)

Design, synthesis, and biological activity of novel 1,2,4-oxadiazole derivatives
por: Zhu, Lingzhi, et al.
Publicado: (2020)

Chitosan/POSS Hybrid Hydrogels for Bone Tissue Engineering
por: Celesti, Consuelo, et al.
Publicado: (2022)

5-(2,4-Dichlorophenyl)-3-(4-nitrophenyl)-1,2,4-oxadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole
por: Yang, Sen, et al.
Publicado: (2020)

A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents
por: Dhameliya, Tejas M., et al.
Publicado: (2022)

Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles
por: Ho, Vien Q. T., et al.
Publicado: (2023)

4-[3-(Chloromethyl)-1,2,4-oxadiazol-5-yl]pyridine. Corrigendum
por: Kang, Si-shun, et al.
Publicado: (2008)

4-[5-(4-Benzoyloxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl benzoate
por: Manjunath, B. C., et al.
Publicado: (2013)

Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives
por: da Silva, Ramon Borges, et al.
Publicado: (2013)

Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
por: Mphahlele, Malose Jack, et al.
Publicado: (2014)

2,3,4-Trihydroxybenzaldehyde
por: Ng, Seik Weng
Publicado: (2008)

Stereoselective Synthesis, Synthetic and Pharmacological Application of Monoterpene-Based 1,2,4- and 1,3,4-Oxadiazoles
por: Gonda, Tímea, et al.
Publicado: (2017)

A Family of Energetic Materials Based on 1,2,4-Oxadiazole and 1,2,5-Oxadiazole Backbones With Low Insensitivity and Good Detonation Performance
por: Xue, Qi, et al.
Publicado: (2020)

Novel biphenyl-substituted 1,2,4-oxadiazole ferroelectric liquid crystals: synthesis and characterization
por: Subrao, Mahabaleshwara, et al.
Publicado: (2015)

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions
por: Puzanov, Andrey I, et al.
Publicado: (2021)

3D-QSAR Studies of 1,2,4-Oxadiazole Derivatives as Sortase A Inhibitors
por: Shakour, Neda, et al.
Publicado: (2021)

Discovery of 1,2,4-Oxadiazole Derivatives Containing Haloalkyl as Potential Acetylcholine Receptor Nematicides
por: Luo, Ling, et al.
Publicado: (2023)

Silver-Assisted [3 + 2] Annulation of Nitrones with Isocyanides: Synthesis of 2,3,4-Trisubstituted 1,2,4-Oxadiazolidin-5-ones
por: Shen, Xuanyu, et al.
Publicado: (2020)

Eco-Friendly 1,3-Dipolar Cycloaddition Reactions on Graphene Quantum Dots in Natural Deep Eutectic Solvent
por: Giofrè, Salvatore V., et al.
Publicado: (2020)

23.4 Briefing
por: LeMaster, Joseph W
Publicado: (2020)

3-[3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl]propanoic acid
por: Zhang, Fang, et al.
Publicado: (2010)

3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors
por: Donnier-Maréchal, Marion, et al.
Publicado: (2015)

1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry
por: Aprile, Silvio, et al.
Publicado: (2021)

Novel 1,2,4-oxadiazole derivatives as selective butyrylcholinesterase inhibitors: Design, synthesis and biological evaluation
por: Nazari, Maryam, et al.
Publicado: (2021)

Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract
por: Pitcher, Noel P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hjdgt17k2fve94c2csktevcivr