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Cell–Matrix Interactions in the Eye: From Cornea to Choroid
The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of n...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003714/ https://www.ncbi.nlm.nih.gov/pubmed/33804633 http://dx.doi.org/10.3390/cells10030687 |
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author | Pouw, Andrew E. Greiner, Mark A. Coussa, Razek G. Jiao, Chunhua Han, Ian C. Skeie, Jessica M. Fingert, John H. Mullins, Robert F. Sohn, Elliott H. |
author_facet | Pouw, Andrew E. Greiner, Mark A. Coussa, Razek G. Jiao, Chunhua Han, Ian C. Skeie, Jessica M. Fingert, John H. Mullins, Robert F. Sohn, Elliott H. |
author_sort | Pouw, Andrew E. |
collection | PubMed |
description | The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of normal physiologic functions of the cornea, vitreous, retina, retinal pigment epithelium, Bruch’s membrane, and choroid as well as trabecular meshwork, optic nerve, conjunctiva and tenon’s layer as it relates to glaucoma. A variety of pathways and key factors related to ECM in the eye are discussed, including but not limited to those related to transforming growth factor-β, vascular endothelial growth factor, basic-fibroblastic growth factor, connective tissue growth factor, matrix metalloproteinases (including MMP-2 and MMP-9, and MMP-14), collagen IV, fibronectin, elastin, canonical signaling, integrins, and endothelial morphogenesis consistent of cellular activation-tubulogenesis and cellular differentiation-stabilization. Alterations contributing to disease states such as wound healing, diabetes-related complications, Fuchs endothelial corneal dystrophy, angiogenesis, fibrosis, age-related macular degeneration, retinal detachment, and posteriorly inserted vitreous base are also reviewed. |
format | Online Article Text |
id | pubmed-8003714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80037142021-03-28 Cell–Matrix Interactions in the Eye: From Cornea to Choroid Pouw, Andrew E. Greiner, Mark A. Coussa, Razek G. Jiao, Chunhua Han, Ian C. Skeie, Jessica M. Fingert, John H. Mullins, Robert F. Sohn, Elliott H. Cells Review The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of normal physiologic functions of the cornea, vitreous, retina, retinal pigment epithelium, Bruch’s membrane, and choroid as well as trabecular meshwork, optic nerve, conjunctiva and tenon’s layer as it relates to glaucoma. A variety of pathways and key factors related to ECM in the eye are discussed, including but not limited to those related to transforming growth factor-β, vascular endothelial growth factor, basic-fibroblastic growth factor, connective tissue growth factor, matrix metalloproteinases (including MMP-2 and MMP-9, and MMP-14), collagen IV, fibronectin, elastin, canonical signaling, integrins, and endothelial morphogenesis consistent of cellular activation-tubulogenesis and cellular differentiation-stabilization. Alterations contributing to disease states such as wound healing, diabetes-related complications, Fuchs endothelial corneal dystrophy, angiogenesis, fibrosis, age-related macular degeneration, retinal detachment, and posteriorly inserted vitreous base are also reviewed. MDPI 2021-03-20 /pmc/articles/PMC8003714/ /pubmed/33804633 http://dx.doi.org/10.3390/cells10030687 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Pouw, Andrew E. Greiner, Mark A. Coussa, Razek G. Jiao, Chunhua Han, Ian C. Skeie, Jessica M. Fingert, John H. Mullins, Robert F. Sohn, Elliott H. Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title | Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title_full | Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title_fullStr | Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title_full_unstemmed | Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title_short | Cell–Matrix Interactions in the Eye: From Cornea to Choroid |
title_sort | cell–matrix interactions in the eye: from cornea to choroid |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003714/ https://www.ncbi.nlm.nih.gov/pubmed/33804633 http://dx.doi.org/10.3390/cells10030687 |
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