Cargando…

Cell–Matrix Interactions in the Eye: From Cornea to Choroid

The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of n...

Descripción completa

Detalles Bibliográficos
Autores principales: Pouw, Andrew E., Greiner, Mark A., Coussa, Razek G., Jiao, Chunhua, Han, Ian C., Skeie, Jessica M., Fingert, John H., Mullins, Robert F., Sohn, Elliott H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003714/
https://www.ncbi.nlm.nih.gov/pubmed/33804633
http://dx.doi.org/10.3390/cells10030687
_version_ 1783671754698260480
author Pouw, Andrew E.
Greiner, Mark A.
Coussa, Razek G.
Jiao, Chunhua
Han, Ian C.
Skeie, Jessica M.
Fingert, John H.
Mullins, Robert F.
Sohn, Elliott H.
author_facet Pouw, Andrew E.
Greiner, Mark A.
Coussa, Razek G.
Jiao, Chunhua
Han, Ian C.
Skeie, Jessica M.
Fingert, John H.
Mullins, Robert F.
Sohn, Elliott H.
author_sort Pouw, Andrew E.
collection PubMed
description The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of normal physiologic functions of the cornea, vitreous, retina, retinal pigment epithelium, Bruch’s membrane, and choroid as well as trabecular meshwork, optic nerve, conjunctiva and tenon’s layer as it relates to glaucoma. A variety of pathways and key factors related to ECM in the eye are discussed, including but not limited to those related to transforming growth factor-β, vascular endothelial growth factor, basic-fibroblastic growth factor, connective tissue growth factor, matrix metalloproteinases (including MMP-2 and MMP-9, and MMP-14), collagen IV, fibronectin, elastin, canonical signaling, integrins, and endothelial morphogenesis consistent of cellular activation-tubulogenesis and cellular differentiation-stabilization. Alterations contributing to disease states such as wound healing, diabetes-related complications, Fuchs endothelial corneal dystrophy, angiogenesis, fibrosis, age-related macular degeneration, retinal detachment, and posteriorly inserted vitreous base are also reviewed.
format Online
Article
Text
id pubmed-8003714
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80037142021-03-28 Cell–Matrix Interactions in the Eye: From Cornea to Choroid Pouw, Andrew E. Greiner, Mark A. Coussa, Razek G. Jiao, Chunhua Han, Ian C. Skeie, Jessica M. Fingert, John H. Mullins, Robert F. Sohn, Elliott H. Cells Review The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of normal physiologic functions of the cornea, vitreous, retina, retinal pigment epithelium, Bruch’s membrane, and choroid as well as trabecular meshwork, optic nerve, conjunctiva and tenon’s layer as it relates to glaucoma. A variety of pathways and key factors related to ECM in the eye are discussed, including but not limited to those related to transforming growth factor-β, vascular endothelial growth factor, basic-fibroblastic growth factor, connective tissue growth factor, matrix metalloproteinases (including MMP-2 and MMP-9, and MMP-14), collagen IV, fibronectin, elastin, canonical signaling, integrins, and endothelial morphogenesis consistent of cellular activation-tubulogenesis and cellular differentiation-stabilization. Alterations contributing to disease states such as wound healing, diabetes-related complications, Fuchs endothelial corneal dystrophy, angiogenesis, fibrosis, age-related macular degeneration, retinal detachment, and posteriorly inserted vitreous base are also reviewed. MDPI 2021-03-20 /pmc/articles/PMC8003714/ /pubmed/33804633 http://dx.doi.org/10.3390/cells10030687 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Pouw, Andrew E.
Greiner, Mark A.
Coussa, Razek G.
Jiao, Chunhua
Han, Ian C.
Skeie, Jessica M.
Fingert, John H.
Mullins, Robert F.
Sohn, Elliott H.
Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title_full Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title_fullStr Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title_full_unstemmed Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title_short Cell–Matrix Interactions in the Eye: From Cornea to Choroid
title_sort cell–matrix interactions in the eye: from cornea to choroid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003714/
https://www.ncbi.nlm.nih.gov/pubmed/33804633
http://dx.doi.org/10.3390/cells10030687
work_keys_str_mv AT pouwandrewe cellmatrixinteractionsintheeyefromcorneatochoroid
AT greinermarka cellmatrixinteractionsintheeyefromcorneatochoroid
AT coussarazekg cellmatrixinteractionsintheeyefromcorneatochoroid
AT jiaochunhua cellmatrixinteractionsintheeyefromcorneatochoroid
AT hanianc cellmatrixinteractionsintheeyefromcorneatochoroid
AT skeiejessicam cellmatrixinteractionsintheeyefromcorneatochoroid
AT fingertjohnh cellmatrixinteractionsintheeyefromcorneatochoroid
AT mullinsrobertf cellmatrixinteractionsintheeyefromcorneatochoroid
AT sohnelliotth cellmatrixinteractionsintheeyefromcorneatochoroid