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Age-Related Palatal Wound Healing: An Experimental In Vivo Study
We assessed age-related excisional palatal mucoperiosteal wound closure in rats. A 4.2 mm diameter punch was used to create a secondary healing defect in the palate of Wistar rats. Study group—21, 18-month-old vs. control 21, 2-month-old males. The 2-dimensional area, maximum length and width of the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003724/ https://www.ncbi.nlm.nih.gov/pubmed/33808882 http://dx.doi.org/10.3390/biology10030240 |
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author | Chaushu, Liat Atzil, Svetlana Vered, Marilena Chaushu, Gavriel Matalon, Shlomo Weinberg, Evgeny |
author_facet | Chaushu, Liat Atzil, Svetlana Vered, Marilena Chaushu, Gavriel Matalon, Shlomo Weinberg, Evgeny |
author_sort | Chaushu, Liat |
collection | PubMed |
description | We assessed age-related excisional palatal mucoperiosteal wound closure in rats. A 4.2 mm diameter punch was used to create a secondary healing defect in the palate of Wistar rats. Study group—21, 18-month-old vs. control 21, 2-month-old males. The 2-dimensional area, maximum length and width of the soft tissue defect served as clinical outcome parameters. The dynamics of the initial three healing weeks were assessed. Semi-quantitative histomorphometric analysis of inflammation and myofibroblasts served for the evaluation of the inflammatory and proliferative wound healing phases. Complete wound closure was faster in the old rats. A dimensional related wound closure was observed in the young rats versus a symmetrical wound closure in the old rats. Inflammatory response was significantly delayed and of lower intensity in the old rats. Myofibroblastic response, representing the proliferative stage, was delayed and of lower intensity in the old rats, albeit not statistically significant. Reduced initial tissue damage due to decreased and delayed inflammatory response in the old rats ultimately led to faster clinical wound healing compared to the young rats, despite a statistically non-significant lower proliferative response in the old rats. |
format | Online Article Text |
id | pubmed-8003724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80037242021-03-28 Age-Related Palatal Wound Healing: An Experimental In Vivo Study Chaushu, Liat Atzil, Svetlana Vered, Marilena Chaushu, Gavriel Matalon, Shlomo Weinberg, Evgeny Biology (Basel) Article We assessed age-related excisional palatal mucoperiosteal wound closure in rats. A 4.2 mm diameter punch was used to create a secondary healing defect in the palate of Wistar rats. Study group—21, 18-month-old vs. control 21, 2-month-old males. The 2-dimensional area, maximum length and width of the soft tissue defect served as clinical outcome parameters. The dynamics of the initial three healing weeks were assessed. Semi-quantitative histomorphometric analysis of inflammation and myofibroblasts served for the evaluation of the inflammatory and proliferative wound healing phases. Complete wound closure was faster in the old rats. A dimensional related wound closure was observed in the young rats versus a symmetrical wound closure in the old rats. Inflammatory response was significantly delayed and of lower intensity in the old rats. Myofibroblastic response, representing the proliferative stage, was delayed and of lower intensity in the old rats, albeit not statistically significant. Reduced initial tissue damage due to decreased and delayed inflammatory response in the old rats ultimately led to faster clinical wound healing compared to the young rats, despite a statistically non-significant lower proliferative response in the old rats. MDPI 2021-03-19 /pmc/articles/PMC8003724/ /pubmed/33808882 http://dx.doi.org/10.3390/biology10030240 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Chaushu, Liat Atzil, Svetlana Vered, Marilena Chaushu, Gavriel Matalon, Shlomo Weinberg, Evgeny Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title | Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title_full | Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title_fullStr | Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title_full_unstemmed | Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title_short | Age-Related Palatal Wound Healing: An Experimental In Vivo Study |
title_sort | age-related palatal wound healing: an experimental in vivo study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003724/ https://www.ncbi.nlm.nih.gov/pubmed/33808882 http://dx.doi.org/10.3390/biology10030240 |
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