Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease †

Vision loss is among the characteristic symptoms of neuronal ceroid lipofuscinosis (NCL), a fatal neurodegenerative lysosomal storage disorder. Here, we performed an in-depth analysis of retinal degeneration at the molecular and cellular levels in mice lacking the lysosomal aspartyl protease catheps...

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Detalles Bibliográficos
Autores principales: Bassal, Mahmoud, Liu, Junling, Jankowiak, Wanda, Saftig, Paul, Bartsch, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003850/
https://www.ncbi.nlm.nih.gov/pubmed/33800998
http://dx.doi.org/10.3390/cells10030696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003850/
https://www.ncbi.nlm.nih.gov/pubmed/33800998
http://dx.doi.org/10.3390/cells10030696

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