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Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease †

Vision loss is among the characteristic symptoms of neuronal ceroid lipofuscinosis (NCL), a fatal neurodegenerative lysosomal storage disorder. Here, we performed an in-depth analysis of retinal degeneration at the molecular and cellular levels in mice lacking the lysosomal aspartyl protease catheps...

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Detalles Bibliográficos
Autores principales:	Bassal, Mahmoud, Liu, Junling, Jankowiak, Wanda, Saftig, Paul, Bartsch, Udo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003850/ https://www.ncbi.nlm.nih.gov/pubmed/33800998 http://dx.doi.org/10.3390/cells10030696

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