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Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003860/ https://www.ncbi.nlm.nih.gov/pubmed/33804729 http://dx.doi.org/10.3390/ijms22063179 |
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author | Behl, Tapan Kaur, Ishnoor Sehgal, Aayush Singh, Sukhbir Zengin, Gokhan Negrut, Nicoleta Nistor-Cseppento, Delia Carmen Pavel, Flavia Maria Corb Aron, Raluca Anca Bungau, Simona |
author_facet | Behl, Tapan Kaur, Ishnoor Sehgal, Aayush Singh, Sukhbir Zengin, Gokhan Negrut, Nicoleta Nistor-Cseppento, Delia Carmen Pavel, Flavia Maria Corb Aron, Raluca Anca Bungau, Simona |
author_sort | Behl, Tapan |
collection | PubMed |
description | Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity. |
format | Online Article Text |
id | pubmed-8003860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80038602021-03-28 Exploring the Genetic Conception of Obesity via the Dual Role of FoxO Behl, Tapan Kaur, Ishnoor Sehgal, Aayush Singh, Sukhbir Zengin, Gokhan Negrut, Nicoleta Nistor-Cseppento, Delia Carmen Pavel, Flavia Maria Corb Aron, Raluca Anca Bungau, Simona Int J Mol Sci Review Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity. MDPI 2021-03-20 /pmc/articles/PMC8003860/ /pubmed/33804729 http://dx.doi.org/10.3390/ijms22063179 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Behl, Tapan Kaur, Ishnoor Sehgal, Aayush Singh, Sukhbir Zengin, Gokhan Negrut, Nicoleta Nistor-Cseppento, Delia Carmen Pavel, Flavia Maria Corb Aron, Raluca Anca Bungau, Simona Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title_full | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title_fullStr | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title_full_unstemmed | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title_short | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
title_sort | exploring the genetic conception of obesity via the dual role of foxo |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003860/ https://www.ncbi.nlm.nih.gov/pubmed/33804729 http://dx.doi.org/10.3390/ijms22063179 |
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