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Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular d...

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Autores principales: Đukanović, Nina, Obradović, Slobodan, Zdravković, Marija, Đurašević, Siniša, Stojković, Maja, Tosti, Tomislav, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003871/
https://www.ncbi.nlm.nih.gov/pubmed/33804754
http://dx.doi.org/10.3390/ijms22063180
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author Đukanović, Nina
Obradović, Slobodan
Zdravković, Marija
Đurašević, Siniša
Stojković, Maja
Tosti, Tomislav
Jasnić, Nebojša
Đorđević, Jelena
Todorović, Zoran
author_facet Đukanović, Nina
Obradović, Slobodan
Zdravković, Marija
Đurašević, Siniša
Stojković, Maja
Tosti, Tomislav
Jasnić, Nebojša
Đorđević, Jelena
Todorović, Zoran
author_sort Đukanović, Nina
collection PubMed
description Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.
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spelling pubmed-80038712021-03-28 Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives Đukanović, Nina Obradović, Slobodan Zdravković, Marija Đurašević, Siniša Stojković, Maja Tosti, Tomislav Jasnić, Nebojša Đorđević, Jelena Todorović, Zoran Int J Mol Sci Review Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets. MDPI 2021-03-20 /pmc/articles/PMC8003871/ /pubmed/33804754 http://dx.doi.org/10.3390/ijms22063180 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Đukanović, Nina
Obradović, Slobodan
Zdravković, Marija
Đurašević, Siniša
Stojković, Maja
Tosti, Tomislav
Jasnić, Nebojša
Đorđević, Jelena
Todorović, Zoran
Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title_full Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title_fullStr Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title_full_unstemmed Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title_short Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
title_sort lipids and antiplatelet therapy: important considerations and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003871/
https://www.ncbi.nlm.nih.gov/pubmed/33804754
http://dx.doi.org/10.3390/ijms22063180
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