The PARP Way to Epigenetic Changes

ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Ummarino, Simone, Hausman, Clinton, Di Ruscio, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003872/
https://www.ncbi.nlm.nih.gov/pubmed/33804735
http://dx.doi.org/10.3390/genes12030446
_version_ 1783671791696216064
author Ummarino, Simone
Hausman, Clinton
Di Ruscio, Annalisa
author_facet Ummarino, Simone
Hausman, Clinton
Di Ruscio, Annalisa
author_sort Ummarino, Simone
collection PubMed
description ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond.
format Online
Article
Text
id pubmed-8003872
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80038722021-03-28 The PARP Way to Epigenetic Changes Ummarino, Simone Hausman, Clinton Di Ruscio, Annalisa Genes (Basel) Review ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond. MDPI 2021-03-20 /pmc/articles/PMC8003872/ /pubmed/33804735 http://dx.doi.org/10.3390/genes12030446 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Ummarino, Simone
Hausman, Clinton
Di Ruscio, Annalisa
The PARP Way to Epigenetic Changes
title The PARP Way to Epigenetic Changes
title_full The PARP Way to Epigenetic Changes
title_fullStr The PARP Way to Epigenetic Changes
title_full_unstemmed The PARP Way to Epigenetic Changes
title_short The PARP Way to Epigenetic Changes
title_sort parp way to epigenetic changes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003872/
https://www.ncbi.nlm.nih.gov/pubmed/33804735
http://dx.doi.org/10.3390/genes12030446
work_keys_str_mv AT ummarinosimone theparpwaytoepigeneticchanges
AT hausmanclinton theparpwaytoepigeneticchanges
AT diruscioannalisa theparpwaytoepigeneticchanges
AT ummarinosimone parpwaytoepigeneticchanges
AT hausmanclinton parpwaytoepigeneticchanges
AT diruscioannalisa parpwaytoepigeneticchanges

Ejemplares similares