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Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy

Background and Aim. Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among pati...

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Autores principales: Senter, Riccardo, Capone, Federico, Pasqualin, Stefano, Cerruti, Lorenzo, Molinari, Leonardo, Fonte Basso, Elisa, Zanforlin, Nicolò, Previato, Lorenzo, Toffolon, Alessandro, Sensi, Caterina, Arcidiacono, Gaetano, Gorgi, Davide, Ippolito, Renato, Nessi, Enrico, Pettenella, Pietro, Cellini, Andrea, Fossa, Claudio, Vania, Eleonora, Gardin, Samuele, Sukthi, Andi, Luise, Dora, Giordani, Maria Teresa, Zanatta, Mirko, Savino, Sandro, Cianci, Vito, Sattin, Andrea, Maria, Anna, Vianello, Andrea, Pesavento, Raffaele, Giannini, Sandro, Avogaro, Angelo, Vettor, Roberto, Fadini, Gian Paolo, Saller, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004000/
https://www.ncbi.nlm.nih.gov/pubmed/33804762
http://dx.doi.org/10.3390/jcm10061288
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author Senter, Riccardo
Capone, Federico
Pasqualin, Stefano
Cerruti, Lorenzo
Molinari, Leonardo
Fonte Basso, Elisa
Zanforlin, Nicolò
Previato, Lorenzo
Toffolon, Alessandro
Sensi, Caterina
Arcidiacono, Gaetano
Gorgi, Davide
Ippolito, Renato
Nessi, Enrico
Pettenella, Pietro
Cellini, Andrea
Fossa, Claudio
Vania, Eleonora
Gardin, Samuele
Sukthi, Andi
Luise, Dora
Giordani, Maria Teresa
Zanatta, Mirko
Savino, Sandro
Cianci, Vito
Sattin, Andrea
Maria, Anna
Vianello, Andrea
Pesavento, Raffaele
Giannini, Sandro
Avogaro, Angelo
Vettor, Roberto
Fadini, Gian Paolo
Saller, Alois
author_facet Senter, Riccardo
Capone, Federico
Pasqualin, Stefano
Cerruti, Lorenzo
Molinari, Leonardo
Fonte Basso, Elisa
Zanforlin, Nicolò
Previato, Lorenzo
Toffolon, Alessandro
Sensi, Caterina
Arcidiacono, Gaetano
Gorgi, Davide
Ippolito, Renato
Nessi, Enrico
Pettenella, Pietro
Cellini, Andrea
Fossa, Claudio
Vania, Eleonora
Gardin, Samuele
Sukthi, Andi
Luise, Dora
Giordani, Maria Teresa
Zanatta, Mirko
Savino, Sandro
Cianci, Vito
Sattin, Andrea
Maria, Anna
Vianello, Andrea
Pesavento, Raffaele
Giannini, Sandro
Avogaro, Angelo
Vettor, Roberto
Fadini, Gian Paolo
Saller, Alois
author_sort Senter, Riccardo
collection PubMed
description Background and Aim. Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among patients with COVID-19 pneumonia. Methods. We performed a retrospective case series analysis of patients with confirmed SARS-CoV-2 infection who were admitted to the hospital because of pneumonia. We recorded history, clinical parameters and medications. LUS was performed and scored in a standardized fashion by experienced operators, with evaluation of up to 12 lung fields, reporting especially on B-lines and consolidations. Results. We included 96 patients, 58.3% men, with a mean age of 65.9 years. Patients with a high-risk quick COVID-19 severity index (qCSI) were older and had worse outcomes, especially for the need for high-flow oxygen. B-lines and consolidations were located mainly in the lower posterior lung fields. LUS patterns for B-lines and consolidations were significantly worse in all lung fields among patients with high versus low qCSI. B-lines and consolidations were worse in the intermediate disease stage, from day 7 to 13 after onset of symptoms. While consolidations correlated more with inflammatory biomarkers, B-lines correlated more with end-organ damage, including extrapulmonary involvement. Conclusions. LUS patterns provide a comprehensive evaluation of patients with COVID-19 pneumonia that correlated with severity and dynamically reflect disease stage. LUS patterns may reflect different pathophysiological processes related to inflammation or tissue damage; consolidations may represent a more specific sign of localized disease, whereas B-lines seem to be also dependent upon generalized illness due to SARS-CoV-2 infection.
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spelling pubmed-80040002021-03-28 Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy Senter, Riccardo Capone, Federico Pasqualin, Stefano Cerruti, Lorenzo Molinari, Leonardo Fonte Basso, Elisa Zanforlin, Nicolò Previato, Lorenzo Toffolon, Alessandro Sensi, Caterina Arcidiacono, Gaetano Gorgi, Davide Ippolito, Renato Nessi, Enrico Pettenella, Pietro Cellini, Andrea Fossa, Claudio Vania, Eleonora Gardin, Samuele Sukthi, Andi Luise, Dora Giordani, Maria Teresa Zanatta, Mirko Savino, Sandro Cianci, Vito Sattin, Andrea Maria, Anna Vianello, Andrea Pesavento, Raffaele Giannini, Sandro Avogaro, Angelo Vettor, Roberto Fadini, Gian Paolo Saller, Alois J Clin Med Article Background and Aim. Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among patients with COVID-19 pneumonia. Methods. We performed a retrospective case series analysis of patients with confirmed SARS-CoV-2 infection who were admitted to the hospital because of pneumonia. We recorded history, clinical parameters and medications. LUS was performed and scored in a standardized fashion by experienced operators, with evaluation of up to 12 lung fields, reporting especially on B-lines and consolidations. Results. We included 96 patients, 58.3% men, with a mean age of 65.9 years. Patients with a high-risk quick COVID-19 severity index (qCSI) were older and had worse outcomes, especially for the need for high-flow oxygen. B-lines and consolidations were located mainly in the lower posterior lung fields. LUS patterns for B-lines and consolidations were significantly worse in all lung fields among patients with high versus low qCSI. B-lines and consolidations were worse in the intermediate disease stage, from day 7 to 13 after onset of symptoms. While consolidations correlated more with inflammatory biomarkers, B-lines correlated more with end-organ damage, including extrapulmonary involvement. Conclusions. LUS patterns provide a comprehensive evaluation of patients with COVID-19 pneumonia that correlated with severity and dynamically reflect disease stage. LUS patterns may reflect different pathophysiological processes related to inflammation or tissue damage; consolidations may represent a more specific sign of localized disease, whereas B-lines seem to be also dependent upon generalized illness due to SARS-CoV-2 infection. MDPI 2021-03-20 /pmc/articles/PMC8004000/ /pubmed/33804762 http://dx.doi.org/10.3390/jcm10061288 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Senter, Riccardo
Capone, Federico
Pasqualin, Stefano
Cerruti, Lorenzo
Molinari, Leonardo
Fonte Basso, Elisa
Zanforlin, Nicolò
Previato, Lorenzo
Toffolon, Alessandro
Sensi, Caterina
Arcidiacono, Gaetano
Gorgi, Davide
Ippolito, Renato
Nessi, Enrico
Pettenella, Pietro
Cellini, Andrea
Fossa, Claudio
Vania, Eleonora
Gardin, Samuele
Sukthi, Andi
Luise, Dora
Giordani, Maria Teresa
Zanatta, Mirko
Savino, Sandro
Cianci, Vito
Sattin, Andrea
Maria, Anna
Vianello, Andrea
Pesavento, Raffaele
Giannini, Sandro
Avogaro, Angelo
Vettor, Roberto
Fadini, Gian Paolo
Saller, Alois
Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title_full Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title_fullStr Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title_full_unstemmed Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title_short Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy
title_sort lung ultrasound patterns and clinical-laboratory correlates during covid-19 pneumonia: a retrospective study from north east italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004000/
https://www.ncbi.nlm.nih.gov/pubmed/33804762
http://dx.doi.org/10.3390/jcm10061288
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