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Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy invol...

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Autores principales: Konstantinidis, Georgios, Tavernarakis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004021/
https://www.ncbi.nlm.nih.gov/pubmed/33800981
http://dx.doi.org/10.3390/cells10030694
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author Konstantinidis, Georgios
Tavernarakis, Nektarios
author_facet Konstantinidis, Georgios
Tavernarakis, Nektarios
author_sort Konstantinidis, Georgios
collection PubMed
description Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode Caenorhabditis elegans.
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spelling pubmed-80040212021-03-28 Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans Konstantinidis, Georgios Tavernarakis, Nektarios Cells Review Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode Caenorhabditis elegans. MDPI 2021-03-21 /pmc/articles/PMC8004021/ /pubmed/33800981 http://dx.doi.org/10.3390/cells10030694 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Konstantinidis, Georgios
Tavernarakis, Nektarios
Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title_full Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title_fullStr Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title_full_unstemmed Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title_short Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
title_sort molecular basis of neuronal autophagy in ageing: insights from caenorhabditis elegans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004021/
https://www.ncbi.nlm.nih.gov/pubmed/33800981
http://dx.doi.org/10.3390/cells10030694
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