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Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans
Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy invol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004021/ https://www.ncbi.nlm.nih.gov/pubmed/33800981 http://dx.doi.org/10.3390/cells10030694 |
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author | Konstantinidis, Georgios Tavernarakis, Nektarios |
author_facet | Konstantinidis, Georgios Tavernarakis, Nektarios |
author_sort | Konstantinidis, Georgios |
collection | PubMed |
description | Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode Caenorhabditis elegans. |
format | Online Article Text |
id | pubmed-8004021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80040212021-03-28 Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans Konstantinidis, Georgios Tavernarakis, Nektarios Cells Review Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode Caenorhabditis elegans. MDPI 2021-03-21 /pmc/articles/PMC8004021/ /pubmed/33800981 http://dx.doi.org/10.3390/cells10030694 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Konstantinidis, Georgios Tavernarakis, Nektarios Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title | Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title_full | Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title_fullStr | Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title_full_unstemmed | Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title_short | Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans |
title_sort | molecular basis of neuronal autophagy in ageing: insights from caenorhabditis elegans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004021/ https://www.ncbi.nlm.nih.gov/pubmed/33800981 http://dx.doi.org/10.3390/cells10030694 |
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