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New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11

The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecu...

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Autores principales: Shi, Ting, Yu, Yan-Yan, Dai, Jia-Jia, Zhang, Yi-Ting, Hu, Wen-Peng, Zheng, Li, Shi, Da-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004129/
https://www.ncbi.nlm.nih.gov/pubmed/33809861
http://dx.doi.org/10.3390/md19030168
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author Shi, Ting
Yu, Yan-Yan
Dai, Jia-Jia
Zhang, Yi-Ting
Hu, Wen-Peng
Zheng, Li
Shi, Da-Yong
author_facet Shi, Ting
Yu, Yan-Yan
Dai, Jia-Jia
Zhang, Yi-Ting
Hu, Wen-Peng
Zheng, Li
Shi, Da-Yong
author_sort Shi, Ting
collection PubMed
description The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2–7). The structure of the new compound was elucidated by extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A (1) is a dimer of diphenyl ketone and diphenyl ether, and there is only one analog of 1 to the best of our knowledge. Compounds 1 and 2 exhibited antibacterial activities against a panel of strains. This is the first time to use molecular networking to study the metabolic profiles of Antarctica fungi.
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spelling pubmed-80041292021-03-28 New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 Shi, Ting Yu, Yan-Yan Dai, Jia-Jia Zhang, Yi-Ting Hu, Wen-Peng Zheng, Li Shi, Da-Yong Mar Drugs Article The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2–7). The structure of the new compound was elucidated by extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A (1) is a dimer of diphenyl ketone and diphenyl ether, and there is only one analog of 1 to the best of our knowledge. Compounds 1 and 2 exhibited antibacterial activities against a panel of strains. This is the first time to use molecular networking to study the metabolic profiles of Antarctica fungi. MDPI 2021-03-22 /pmc/articles/PMC8004129/ /pubmed/33809861 http://dx.doi.org/10.3390/md19030168 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Shi, Ting
Yu, Yan-Yan
Dai, Jia-Jia
Zhang, Yi-Ting
Hu, Wen-Peng
Zheng, Li
Shi, Da-Yong
New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title_full New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title_fullStr New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title_full_unstemmed New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title_short New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
title_sort new polyketides from the antarctic fungus pseudogymnoascus sp. hsx2#-11
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004129/
https://www.ncbi.nlm.nih.gov/pubmed/33809861
http://dx.doi.org/10.3390/md19030168
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