Cargando…
New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004129/ https://www.ncbi.nlm.nih.gov/pubmed/33809861 http://dx.doi.org/10.3390/md19030168 |
_version_ | 1783671852446515200 |
---|---|
author | Shi, Ting Yu, Yan-Yan Dai, Jia-Jia Zhang, Yi-Ting Hu, Wen-Peng Zheng, Li Shi, Da-Yong |
author_facet | Shi, Ting Yu, Yan-Yan Dai, Jia-Jia Zhang, Yi-Ting Hu, Wen-Peng Zheng, Li Shi, Da-Yong |
author_sort | Shi, Ting |
collection | PubMed |
description | The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2–7). The structure of the new compound was elucidated by extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A (1) is a dimer of diphenyl ketone and diphenyl ether, and there is only one analog of 1 to the best of our knowledge. Compounds 1 and 2 exhibited antibacterial activities against a panel of strains. This is the first time to use molecular networking to study the metabolic profiles of Antarctica fungi. |
format | Online Article Text |
id | pubmed-8004129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80041292021-03-28 New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 Shi, Ting Yu, Yan-Yan Dai, Jia-Jia Zhang, Yi-Ting Hu, Wen-Peng Zheng, Li Shi, Da-Yong Mar Drugs Article The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2–7). The structure of the new compound was elucidated by extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A (1) is a dimer of diphenyl ketone and diphenyl ether, and there is only one analog of 1 to the best of our knowledge. Compounds 1 and 2 exhibited antibacterial activities against a panel of strains. This is the first time to use molecular networking to study the metabolic profiles of Antarctica fungi. MDPI 2021-03-22 /pmc/articles/PMC8004129/ /pubmed/33809861 http://dx.doi.org/10.3390/md19030168 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Shi, Ting Yu, Yan-Yan Dai, Jia-Jia Zhang, Yi-Ting Hu, Wen-Peng Zheng, Li Shi, Da-Yong New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title | New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_full | New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_fullStr | New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_full_unstemmed | New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_short | New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_sort | new polyketides from the antarctic fungus pseudogymnoascus sp. hsx2#-11 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004129/ https://www.ncbi.nlm.nih.gov/pubmed/33809861 http://dx.doi.org/10.3390/md19030168 |
work_keys_str_mv | AT shiting newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT yuyanyan newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT daijiajia newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT zhangyiting newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT huwenpeng newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT zhengli newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 AT shidayong newpolyketidesfromtheantarcticfunguspseudogymnoascussphsx211 |