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Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles †

Phosphodiesterase 7 (PDE7) is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP), an important cellular messenger. PDE7’s role in neurotransmission, expression profile in the brain and the druggability of other phosphodiesterases have motivated the search for potent i...

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Detalles Bibliográficos
Autores principales:	Nozal, Vanesa, Rojas-Prats, Elisa, Maestro, Inés, Gil, Carmen, Perez, Daniel I., Martinez, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004175/ https://www.ncbi.nlm.nih.gov/pubmed/33809846 http://dx.doi.org/10.3390/ijms22063206

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