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Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series

Novel antimicrobial wound dressings impregnated with copper oxide micro-particles have been cleared for treatment of acute and chronic wounds. Our objective is to provide preliminary data regarding the potential benefit of using these novel wound dressings including in non-infected wounds. Methods i...

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Autores principales: Melamed, Eyal, Kiambi, Patrick, Okoth, Dancan, Honigber, Irena, Tamir, Eran, Borkow, Gadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004176/
https://www.ncbi.nlm.nih.gov/pubmed/33809898
http://dx.doi.org/10.3390/medicina57030296
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author Melamed, Eyal
Kiambi, Patrick
Okoth, Dancan
Honigber, Irena
Tamir, Eran
Borkow, Gadi
author_facet Melamed, Eyal
Kiambi, Patrick
Okoth, Dancan
Honigber, Irena
Tamir, Eran
Borkow, Gadi
author_sort Melamed, Eyal
collection PubMed
description Novel antimicrobial wound dressings impregnated with copper oxide micro-particles have been cleared for treatment of acute and chronic wounds. Our objective is to provide preliminary data regarding the potential benefit of using these novel wound dressings including in non-infected wounds. Methods involved the treatment of wounds that responded partially or poorly to conventional wound healing treatments with copper oxide impregnated wound dressings in patients with a range of etiologies. Ten cases of patients with etiologies such as diabetes mellitus, sickle cell disease, renal failure, and necrotizing fasciitis, in which the application of copper oxide impregnated wound dressings in infected and non-infected wounds, which resulted in significant enhanced wound healing, are presented. This was exemplified by clearing of the wound infections, reduction of the fibrous and/or necrotic tissue and by intense granulation, epithelialization, and wound closure. The described 10 case reports support our hypothesis that the copper oxide-containing wound dressing not only confers protection to the wound and the dressing from microbial contamination, and in some cases may help clear the wound infections, but in addition and more importantly, stimulate skin regeneration and wound healing. Our findings are in line with previous animal and in vitro studies showing that copper plays a key role in angiogenesis and skin regeneration. These case reports support the notion that the use of copper oxide impregnated wound dressings may be an important intervention in the arsenal of wound treatment modalities, especially in hard to heal wounds.
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spelling pubmed-80041762021-03-28 Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series Melamed, Eyal Kiambi, Patrick Okoth, Dancan Honigber, Irena Tamir, Eran Borkow, Gadi Medicina (Kaunas) Case Report Novel antimicrobial wound dressings impregnated with copper oxide micro-particles have been cleared for treatment of acute and chronic wounds. Our objective is to provide preliminary data regarding the potential benefit of using these novel wound dressings including in non-infected wounds. Methods involved the treatment of wounds that responded partially or poorly to conventional wound healing treatments with copper oxide impregnated wound dressings in patients with a range of etiologies. Ten cases of patients with etiologies such as diabetes mellitus, sickle cell disease, renal failure, and necrotizing fasciitis, in which the application of copper oxide impregnated wound dressings in infected and non-infected wounds, which resulted in significant enhanced wound healing, are presented. This was exemplified by clearing of the wound infections, reduction of the fibrous and/or necrotic tissue and by intense granulation, epithelialization, and wound closure. The described 10 case reports support our hypothesis that the copper oxide-containing wound dressing not only confers protection to the wound and the dressing from microbial contamination, and in some cases may help clear the wound infections, but in addition and more importantly, stimulate skin regeneration and wound healing. Our findings are in line with previous animal and in vitro studies showing that copper plays a key role in angiogenesis and skin regeneration. These case reports support the notion that the use of copper oxide impregnated wound dressings may be an important intervention in the arsenal of wound treatment modalities, especially in hard to heal wounds. MDPI 2021-03-22 /pmc/articles/PMC8004176/ /pubmed/33809898 http://dx.doi.org/10.3390/medicina57030296 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Case Report
Melamed, Eyal
Kiambi, Patrick
Okoth, Dancan
Honigber, Irena
Tamir, Eran
Borkow, Gadi
Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title_full Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title_fullStr Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title_full_unstemmed Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title_short Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
title_sort healing of chronic wounds by copper oxide-impregnated wound dressings—case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004176/
https://www.ncbi.nlm.nih.gov/pubmed/33809898
http://dx.doi.org/10.3390/medicina57030296
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