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The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection

The novel coronavirus disease 2019 (COVID-19) pandemic has led to an unprecedented threat to the international community and raised major concerns in terms of public health safety. Although our current understanding of the complexity of COVID-19 pathogenesis remains limited, the infection is largely...

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Autores principales: Kaseb, Ahmed O., Mohamed, Yehia I., Malek, Alexandre E., Raad, Issam I., Altameemi, Lina, Li, Dan, Kaseb, Omar A., Kaseb, Safa A., Selim, Abdelhafez, Ma, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004186/
https://www.ncbi.nlm.nih.gov/pubmed/33809851
http://dx.doi.org/10.3390/pathogens10030379
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author Kaseb, Ahmed O.
Mohamed, Yehia I.
Malek, Alexandre E.
Raad, Issam I.
Altameemi, Lina
Li, Dan
Kaseb, Omar A.
Kaseb, Safa A.
Selim, Abdelhafez
Ma, Qing
author_facet Kaseb, Ahmed O.
Mohamed, Yehia I.
Malek, Alexandre E.
Raad, Issam I.
Altameemi, Lina
Li, Dan
Kaseb, Omar A.
Kaseb, Safa A.
Selim, Abdelhafez
Ma, Qing
author_sort Kaseb, Ahmed O.
collection PubMed
description The novel coronavirus disease 2019 (COVID-19) pandemic has led to an unprecedented threat to the international community and raised major concerns in terms of public health safety. Although our current understanding of the complexity of COVID-19 pathogenesis remains limited, the infection is largely mediated by the interaction of viral spike protein and angiotensin-converting enzyme 2 (ACE2). The functional importance of ACE2 in different demographic and comorbid conditions may explain the significant variation in incidence and mortality of COVID-19 in vulnerable groups, and highlights its candidacy as a potential therapeutic target. We provide evidence supporting the idea that differences in incidence and severity of COVID-19 infection may be related to ACE2. Emerging data based on the prevalence and severity of COVID-19 among those with established high levels of ACE2 expression strongly support our hypothesis. Considering the burden of COVID-19 infection in these vulnerable groups and the impact of the potential therapeutic and preventive measures that would result from adopting ACE2-driven anti-viral strategies, our hypothesis may expedite global efforts to control the current COVID-19 pandemic.
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spelling pubmed-80041862021-03-28 The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection Kaseb, Ahmed O. Mohamed, Yehia I. Malek, Alexandre E. Raad, Issam I. Altameemi, Lina Li, Dan Kaseb, Omar A. Kaseb, Safa A. Selim, Abdelhafez Ma, Qing Pathogens Review The novel coronavirus disease 2019 (COVID-19) pandemic has led to an unprecedented threat to the international community and raised major concerns in terms of public health safety. Although our current understanding of the complexity of COVID-19 pathogenesis remains limited, the infection is largely mediated by the interaction of viral spike protein and angiotensin-converting enzyme 2 (ACE2). The functional importance of ACE2 in different demographic and comorbid conditions may explain the significant variation in incidence and mortality of COVID-19 in vulnerable groups, and highlights its candidacy as a potential therapeutic target. We provide evidence supporting the idea that differences in incidence and severity of COVID-19 infection may be related to ACE2. Emerging data based on the prevalence and severity of COVID-19 among those with established high levels of ACE2 expression strongly support our hypothesis. Considering the burden of COVID-19 infection in these vulnerable groups and the impact of the potential therapeutic and preventive measures that would result from adopting ACE2-driven anti-viral strategies, our hypothesis may expedite global efforts to control the current COVID-19 pandemic. MDPI 2021-03-22 /pmc/articles/PMC8004186/ /pubmed/33809851 http://dx.doi.org/10.3390/pathogens10030379 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Kaseb, Ahmed O.
Mohamed, Yehia I.
Malek, Alexandre E.
Raad, Issam I.
Altameemi, Lina
Li, Dan
Kaseb, Omar A.
Kaseb, Safa A.
Selim, Abdelhafez
Ma, Qing
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title_full The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title_fullStr The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title_full_unstemmed The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title_short The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
title_sort impact of angiotensin-converting enzyme 2 (ace2) expression on the incidence and severity of covid-19 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004186/
https://www.ncbi.nlm.nih.gov/pubmed/33809851
http://dx.doi.org/10.3390/pathogens10030379
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