Cargando…

Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology

(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diasto...

Descripción completa

Detalles Bibliográficos
Autores principales: Tudoran, Mariana, Tudoran, Cristina, Lazureanu, Voichita Elena, Marinescu, Adelina Raluca, Pop, Gheorghe Nicusor, Pescariu, Alexandru Silvius, Enache, Alexandra, Cut, Talida Georgiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004210/
https://www.ncbi.nlm.nih.gov/pubmed/33809873
http://dx.doi.org/10.3390/jpm11030225
_version_ 1783671871447760896
author Tudoran, Mariana
Tudoran, Cristina
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
author_facet Tudoran, Mariana
Tudoran, Cristina
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
author_sort Tudoran, Mariana
collection PubMed
description (1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6–10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
format Online
Article
Text
id pubmed-8004210
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80042102021-03-28 Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology Tudoran, Mariana Tudoran, Cristina Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana J Pers Med Article (1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6–10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance. MDPI 2021-03-22 /pmc/articles/PMC8004210/ /pubmed/33809873 http://dx.doi.org/10.3390/jpm11030225 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Tudoran, Mariana
Tudoran, Cristina
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title_full Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title_fullStr Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title_full_unstemmed Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title_short Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology
title_sort alterations of left ventricular function persisting during post-acute covid-19 in subjects without previously diagnosed cardiovascular pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004210/
https://www.ncbi.nlm.nih.gov/pubmed/33809873
http://dx.doi.org/10.3390/jpm11030225
work_keys_str_mv AT tudoranmariana alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT tudorancristina alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT lazureanuvoichitaelena alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT marinescuadelinaraluca alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT popgheorghenicusor alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT pescariualexandrusilvius alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT enachealexandra alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology
AT cuttalidageorgiana alterationsofleftventricularfunctionpersistingduringpostacutecovid19insubjectswithoutpreviouslydiagnosedcardiovascularpathology