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Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells

SIMPLE SUMMARY: In cancer cells, the DNA repair response can be exploited as an ‘Achilles heel’ to trigger programmed cell death pathways and tumor elimination. Rather than involving ‘naked’ DNA, repair occurs in the context of histone and non-histone proteins in the vicinity of the damage. Drugs th...

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Detalles Bibliográficos
Autores principales:	Kapoor, Sabeeta, Gustafson, Trace, Zhang, Mutian, Chen, Ying-Shiuan, Li, Jia, Nguyen, Nhung, Perez, Jorge Enrique Tovar, Dashwood, Wan Mohaiza, Rajendran, Praveen, Dashwood, Roderick H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004213/ https://www.ncbi.nlm.nih.gov/pubmed/33809839 http://dx.doi.org/10.3390/cancers13061438

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