Cargando…
Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinee...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004292/ https://www.ncbi.nlm.nih.gov/pubmed/33809834 http://dx.doi.org/10.3390/medicina57030292 |
_version_ | 1783671890715344896 |
---|---|
author | Suša, Romana Ćupurdija, Vojislav Novković, Ljiljana Ratinac, Miloš Janković, Slobodan Đoković, Danijela Jovanović, Jovan Pantić, Katarina Simović, Stefan Bazić-Sretenović, Danijela Čekerevac, Ivan |
author_facet | Suša, Romana Ćupurdija, Vojislav Novković, Ljiljana Ratinac, Miloš Janković, Slobodan Đoković, Danijela Jovanović, Jovan Pantić, Katarina Simović, Stefan Bazić-Sretenović, Danijela Čekerevac, Ivan |
author_sort | Suša, Romana |
collection | PubMed |
description | Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea–hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). Results: We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI (r = 0.633, p < 0.001), as well as with body fat percentage (r = 0.450, p = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) (r = 0.579, p = 0.003) and lean body mass (r = −0.501, p = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. Conclusions: Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA. |
format | Online Article Text |
id | pubmed-8004292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80042922021-03-28 Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? Suša, Romana Ćupurdija, Vojislav Novković, Ljiljana Ratinac, Miloš Janković, Slobodan Đoković, Danijela Jovanović, Jovan Pantić, Katarina Simović, Stefan Bazić-Sretenović, Danijela Čekerevac, Ivan Medicina (Kaunas) Article Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea–hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). Results: We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI (r = 0.633, p < 0.001), as well as with body fat percentage (r = 0.450, p = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) (r = 0.579, p = 0.003) and lean body mass (r = −0.501, p = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. Conclusions: Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA. MDPI 2021-03-22 /pmc/articles/PMC8004292/ /pubmed/33809834 http://dx.doi.org/10.3390/medicina57030292 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Suša, Romana Ćupurdija, Vojislav Novković, Ljiljana Ratinac, Miloš Janković, Slobodan Đoković, Danijela Jovanović, Jovan Pantić, Katarina Simović, Stefan Bazić-Sretenović, Danijela Čekerevac, Ivan Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title | Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title_full | Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title_fullStr | Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title_full_unstemmed | Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title_short | Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? |
title_sort | does the severity of obstructive sleep apnea have an independent impact on systemic inflammation? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004292/ https://www.ncbi.nlm.nih.gov/pubmed/33809834 http://dx.doi.org/10.3390/medicina57030292 |
work_keys_str_mv | AT susaromana doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT cupurdijavojislav doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT novkovicljiljana doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT ratinacmilos doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT jankovicslobodan doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT đokovicdanijela doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT jovanovicjovan doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT pantickatarina doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT simovicstefan doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT bazicsretenovicdanijela doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation AT cekerevacivan doestheseverityofobstructivesleepapneahaveanindependentimpactonsystemicinflammation |