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Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?

Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinee...

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Autores principales: Suša, Romana, Ćupurdija, Vojislav, Novković, Ljiljana, Ratinac, Miloš, Janković, Slobodan, Đoković, Danijela, Jovanović, Jovan, Pantić, Katarina, Simović, Stefan, Bazić-Sretenović, Danijela, Čekerevac, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004292/
https://www.ncbi.nlm.nih.gov/pubmed/33809834
http://dx.doi.org/10.3390/medicina57030292
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author Suša, Romana
Ćupurdija, Vojislav
Novković, Ljiljana
Ratinac, Miloš
Janković, Slobodan
Đoković, Danijela
Jovanović, Jovan
Pantić, Katarina
Simović, Stefan
Bazić-Sretenović, Danijela
Čekerevac, Ivan
author_facet Suša, Romana
Ćupurdija, Vojislav
Novković, Ljiljana
Ratinac, Miloš
Janković, Slobodan
Đoković, Danijela
Jovanović, Jovan
Pantić, Katarina
Simović, Stefan
Bazić-Sretenović, Danijela
Čekerevac, Ivan
author_sort Suša, Romana
collection PubMed
description Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea–hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). Results: We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI (r = 0.633, p < 0.001), as well as with body fat percentage (r = 0.450, p = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) (r = 0.579, p = 0.003) and lean body mass (r = −0.501, p = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. Conclusions: Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA.
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spelling pubmed-80042922021-03-28 Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation? Suša, Romana Ćupurdija, Vojislav Novković, Ljiljana Ratinac, Miloš Janković, Slobodan Đoković, Danijela Jovanović, Jovan Pantić, Katarina Simović, Stefan Bazić-Sretenović, Danijela Čekerevac, Ivan Medicina (Kaunas) Article Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea–hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). Results: We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI (r = 0.633, p < 0.001), as well as with body fat percentage (r = 0.450, p = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) (r = 0.579, p = 0.003) and lean body mass (r = −0.501, p = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. Conclusions: Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA. MDPI 2021-03-22 /pmc/articles/PMC8004292/ /pubmed/33809834 http://dx.doi.org/10.3390/medicina57030292 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Suša, Romana
Ćupurdija, Vojislav
Novković, Ljiljana
Ratinac, Miloš
Janković, Slobodan
Đoković, Danijela
Jovanović, Jovan
Pantić, Katarina
Simović, Stefan
Bazić-Sretenović, Danijela
Čekerevac, Ivan
Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title_full Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title_fullStr Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title_full_unstemmed Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title_short Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?
title_sort does the severity of obstructive sleep apnea have an independent impact on systemic inflammation?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004292/
https://www.ncbi.nlm.nih.gov/pubmed/33809834
http://dx.doi.org/10.3390/medicina57030292
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