Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

BACKGROUND: Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prophylactic treatment with a CatS inhibitor from birt...

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Detalles Bibliográficos
Autores principales: Brown, Ryan, Small, Donna M., Doherty, Declan F., Holsinger, Leslie, Booth, Robert, Williams, Richard, Ingram, Rebecca J., Elborn, J. Stuart, Mall, Marcus A., Taggart, Clifford C., Weldon, Sinéad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004367/
https://www.ncbi.nlm.nih.gov/pubmed/33828414
http://dx.doi.org/10.1155/2021/6682657

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