Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy

Macrophage M1 polarization mediates inflammatory responses and tissue damage. Recently, aldose reductase (AR) has been shown to play a critical role in M1 polarization in macrophages. However, the underlying mechanisms are unknown. Here, we demonstrated, for the first time, that AR deficiency repres...

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Detalles Bibliográficos
Autores principales: Cheng, Peng, Xie, Jianwei, Liu, Zhiyong, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004403/
https://www.ncbi.nlm.nih.gov/pubmed/33771228
http://dx.doi.org/10.1186/s13578-021-00576-7

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