Cargando…

miR-146a regulates insulin sensitivity via NPR3

The pathogenesis of obesity-related metabolic diseases has been linked to the inflammation of white adipose tissue (WAT), but the molecular interconnections are still not fully understood. MiR-146a controls inflammatory processes by suppressing pro-inflammatory signaling pathways. The aim of this st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roos, Julian, Dahlhaus, Meike, Funcke, Jan-Bernd, Kustermann, Monika, Strauss, Gudrun, Halbgebauer, Daniel, Boldrin, Elena, Holzmann, Karlheinz, Möller, Peter, Trojanowski, Bernadette M., Baumann, Bernd, Debatin, Klaus-Michael, Wabitsch, Martin, Fischer-Posovszky, Pamela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004521/ https://www.ncbi.nlm.nih.gov/pubmed/33206203 http://dx.doi.org/10.1007/s00018-020-03699-1

Ejemplares similares

miR-146a-mediated suppression of the inflammatory response in human adipocytes
por: Roos, Julian, et al.
Publicado: (2016)

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes
por: Zoller, Verena, et al.
Publicado: (2017)

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation
por: Dahlhaus, Meike, et al.
Publicado: (2020)

Monogenic forms of childhood obesity due to mutations in the leptin gene
por: Funcke, Jan-Bernd, et al.
Publicado: (2014)

Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells
por: Halbgebauer, D., et al.
Publicado: (2020)

TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors
por: Zoller, Verena, et al.
Publicado: (2016)

Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2
por: Halbgebauer, D., et al.
Publicado: (2021)

Resveratrol Suppresses PAI-1 Gene Expression in a Human In Vitro Model of Inflamed Adipose Tissue
por: Zagotta, Ivana, et al.
Publicado: (2013)

Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children
por: Gaebler, Niklas, et al.
Publicado: (2019)

Estimated prevalence of potentially damaging variants in the leptin gene
por: Nunziata, Adriana, et al.
Publicado: (2017)

In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease
por: Reisser, Tanja, et al.
Publicado: (2020)

Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes
por: Tews, D., et al.
Publicado: (2019)

Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations
por: Nunziata, Adriana, et al.
Publicado: (2018)

Adoptively Transferred in vitro-Generated Myeloid-Derived Suppressor Cells Improve T-Cell Function and Antigen-Specific Immunity after Traumatic Lung Injury
por: Kustermann, Monika, et al.
Publicado: (2022)

microRNA-27a-3p but Not -5p Is a Crucial Mediator of Human Adipogenesis
por: Wu, Hang, et al.
Publicado: (2021)

Establishment of Lipofection for Studying miRNA Function in Human Adipocytes
por: Enlund, Eveliina, et al.
Publicado: (2014)

Adipose tissue: a neglected organ in the response to severe trauma?
por: Wrba, Lisa, et al.
Publicado: (2022)

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue
por: Zagotta, Ivana, et al.
Publicado: (2015)

20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology
por: Tews, Daniel, et al.
Publicado: (2022)

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma
por: Keuper, M, et al.
Publicado: (2013)

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene
por: Wabitsch, Martin, et al.
Publicado: (2015)

Immunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest trauma
por: Kustermann, Monika, et al.
Publicado: (2019)

Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents
por: KOTNIK, Primož, et al.
Publicado: (2015)

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?
por: Zinngrebe, Julia, et al.
Publicado: (2020)

Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency
por: Wabitsch, Martin, et al.
Publicado: (2016)

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach
por: Mettang, Melanie, et al.
Publicado: (2018)

Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis
por: Schleker, Teresa, et al.
Publicado: (2018)

Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes
por: Kotnik, Primoz, et al.
Publicado: (2013)

Integrating data on the Arabidopsis NPR1/NPR3/NPR4 salicylic acid receptors; a differentiating argument
por: Kuai, Xiahezi, et al.
Publicado: (2015)

The Arabidopsis NIMIN proteins affect NPR1 differentially
por: Hermann, Meike, et al.
Publicado: (2013)

Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS
por: Zinngrebe, Julia, et al.
Publicado: (2022)

PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449
por: Galiger, Celimene, et al.
Publicado: (2022)

NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants
por: Fu, Zheng Qing, et al.
Publicado: (2012)

THP-1 Macrophages and SGBS Adipocytes – A New Human in vitro Model System of Inflamed Adipose Tissue
por: Keuper, Michaela, et al.
Publicado: (2011)

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses
por: Hüsecken, Yvonne, et al.
Publicado: (2017)

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
por: Subramanian, Hariharan, et al.
Publicado: (2018)

Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance
por: Roos, Julian, et al.
Publicado: (2021)

Prevalence estimates of putatively pathogenic leptin variants in the gnomAD database
por: Rajcsanyi, Luisa Sophie, et al.
Publicado: (2022)

Unraveling NPR-like Family Genes in Fragaria spp. Facilitated to Identify Putative NPR1 and NPR3/4 Orthologues Participating in Strawberry-Colletotrichum fructicola Interaction
por: Bai, Yun, et al.
Publicado: (2022)

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
por: Wu, Xi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_eavs2svsf49u5i1jh730h0e0qo