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Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers

PURPOSE: The study aimed to determine the incidence and long-term evolution of COVID-related olfactory (OD) and gustatory (GD) dysfunction, the recovery timeline, and the association with other symptoms. The secondary objective was to identify the predictive clinical factors for the evolution of the...

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Autores principales: Riestra-Ayora, Juan, Yanes-Diaz, Joaquin, Esteban-Sanchez, Jonathan, Vaduva, Cristina, Molina-Quiros, Cristina, Larran-Jimenez, Alba, Martin-Sanz, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004560/
https://www.ncbi.nlm.nih.gov/pubmed/33774737
http://dx.doi.org/10.1007/s00405-021-06764-y
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author Riestra-Ayora, Juan
Yanes-Diaz, Joaquin
Esteban-Sanchez, Jonathan
Vaduva, Cristina
Molina-Quiros, Cristina
Larran-Jimenez, Alba
Martin-Sanz, Eduardo
author_facet Riestra-Ayora, Juan
Yanes-Diaz, Joaquin
Esteban-Sanchez, Jonathan
Vaduva, Cristina
Molina-Quiros, Cristina
Larran-Jimenez, Alba
Martin-Sanz, Eduardo
author_sort Riestra-Ayora, Juan
collection PubMed
description PURPOSE: The study aimed to determine the incidence and long-term evolution of COVID-related olfactory (OD) and gustatory (GD) dysfunction, the recovery timeline, and the association with other symptoms. The secondary objective was to identify the predictive clinical factors for the evolution of these symptoms. METHODS: A prospective case–control study was conducted from March 15 to October 15, 2020, in health workers with COVID-19 related symptoms in a tertiary care hospital. 320 patients were included after 6 months of follow-up: 195 in the case group and 125 in the control group. Olfactory dysfunction (OD), dysosmia, and gustatory dysfunction (GD) onset and recovery rate after 6 months follow-up are analyzed in both groups. RESULTS: There were 125 (64.1%) in case group patients with OD and 118 (60.5%) with GD. Total or partial recovery OD and GD was found in 89%, mainly in the first 2 months. In the control group, there were 14 (11.2%) patients with OD and 33 (26.4%) patients with GD, with 100% of total/partial recovery. CONCLUSION: In both groups, OD and GD showed high-resolution rates during the first two months after the onset of symptoms. Nevertheless, 11% of the case group patients did not show any recovery, and the partial resolution was present in 30% of our patients, at the 6 months follow-up. We found a high correlation between OD and GD, both in the appearance of symptoms and in their recovery. Nasal obstruction and dyspnea have been identified as risk factors for the persistence of symptoms.
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spelling pubmed-80045602021-03-29 Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers Riestra-Ayora, Juan Yanes-Diaz, Joaquin Esteban-Sanchez, Jonathan Vaduva, Cristina Molina-Quiros, Cristina Larran-Jimenez, Alba Martin-Sanz, Eduardo Eur Arch Otorhinolaryngol Rhinology PURPOSE: The study aimed to determine the incidence and long-term evolution of COVID-related olfactory (OD) and gustatory (GD) dysfunction, the recovery timeline, and the association with other symptoms. The secondary objective was to identify the predictive clinical factors for the evolution of these symptoms. METHODS: A prospective case–control study was conducted from March 15 to October 15, 2020, in health workers with COVID-19 related symptoms in a tertiary care hospital. 320 patients were included after 6 months of follow-up: 195 in the case group and 125 in the control group. Olfactory dysfunction (OD), dysosmia, and gustatory dysfunction (GD) onset and recovery rate after 6 months follow-up are analyzed in both groups. RESULTS: There were 125 (64.1%) in case group patients with OD and 118 (60.5%) with GD. Total or partial recovery OD and GD was found in 89%, mainly in the first 2 months. In the control group, there were 14 (11.2%) patients with OD and 33 (26.4%) patients with GD, with 100% of total/partial recovery. CONCLUSION: In both groups, OD and GD showed high-resolution rates during the first two months after the onset of symptoms. Nevertheless, 11% of the case group patients did not show any recovery, and the partial resolution was present in 30% of our patients, at the 6 months follow-up. We found a high correlation between OD and GD, both in the appearance of symptoms and in their recovery. Nasal obstruction and dyspnea have been identified as risk factors for the persistence of symptoms. Springer Berlin Heidelberg 2021-03-28 2021 /pmc/articles/PMC8004560/ /pubmed/33774737 http://dx.doi.org/10.1007/s00405-021-06764-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Rhinology
Riestra-Ayora, Juan
Yanes-Diaz, Joaquin
Esteban-Sanchez, Jonathan
Vaduva, Cristina
Molina-Quiros, Cristina
Larran-Jimenez, Alba
Martin-Sanz, Eduardo
Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title_full Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title_fullStr Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title_full_unstemmed Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title_short Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case–control study of health workers
title_sort long-term follow-up of olfactory and gustatory dysfunction in covid-19: 6 months case–control study of health workers
topic Rhinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004560/
https://www.ncbi.nlm.nih.gov/pubmed/33774737
http://dx.doi.org/10.1007/s00405-021-06764-y
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