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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY(®)) Antibody–Drug Conjugate in Sprague Dawley Rats
Polatuzumab vedotin (or POLIVY(®)), an antibody–drug conjugate (ADC) composed of a polatuzumab monoclonal antibody conjugated to monomethyl auristatin E (MMAE) via a cleavable dipeptide linker, has been approved by the United States Food and Drug Administration (FDA) for the treatment of diffuse lar...
Autores principales: | Yip, Victor, Lee, M. Violet, Saad, Ola M., Ma, Shuguang, Khojasteh, S. Cyrus, Shen, Ben-Quan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004598/ https://www.ncbi.nlm.nih.gov/pubmed/33806916 http://dx.doi.org/10.3390/jcm10061323 |
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